Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 367

Special Issue Editor

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Guest Editor
MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400377 Cluj-Napoca, Romania
Interests: signaling pathways; biochemistry; cell-culture; cell death mechanism; cancer research; hematology
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Special Issue Information

Dear Colleagues,

Cancer initiation and progression are driven by a complex interplay of genetic errors, environmental factors, and dysregulated molecular pathways. Among these pathways, the mechanism of cell death plays a critical role in regulating tumor growth and survival. Alterations in cell death pathways enable cancer cells to evade apoptosis, proliferate uncontrollably, and resist therapy. Therefore, targeting these pathways represents a promising therapeutic strategy for combating cancer.

This Special Issue aims to showcase cutting-edge research focused on elucidating the molecular mechanisms underlying cell death dysregulation in cancer and identifying novel therapeutic compounds capable of restoring its normal function. The featured studies will highlight both newly discovered molecules and repurposed drugs, offering insights into innovative strategies for overcoming treatment resistance and improving patient outcomes in both solid tumors and hematological malignancies.

The research presented in this collection will delve into the intricate molecular events driving cell death dysregulation in cancer, including disruptions in signaling cascades, DNA repair mechanisms, and the aberrant expression of regulatory proteins. Furthermore, the impact of environmental factors such as carcinogen exposure and chronic inflammation on these processes will be explored. By unraveling the complex mechanisms governing cell death in cancer, researchers aim to identify vulnerabilities that can be exploited for therapeutic intervention.

Through comprehensive exploration of the cell death machinery, this Special Issue seeks to accelerate the development of effective anti-cancer therapies with broad applicability across diverse cancer types. By highlighting promising compounds and therapeutic approaches, the collection aims to provide valuable insights into the future of cancer treatment and pave the way for improved outcomes for patients worldwide.

Dr. Adrian-Bogdan Țigu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell death
  • drug repositioning
  • translational research
  • oncology
  • cancer therapy
  • apoptosis

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