Special Issue "Skin Fibrosis and Cutaneous Wound Healing"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 2634
During the wound healing process, epithelialization is completed and remodeling of the extracellular matrix that makes up the granulation tissue occurs. Fibroblasts and leukocytes disappear from the granulation tissue formed during the proliferative phase, and collagen fibers are altered to form scar tissue. Granulation tissue contains large amounts of type III collagen, which diminishes during maturation and is replaced by type I collagen. Collagen polymerizes through cross-linking, increasing the support and tensile strength of the scar. If inflammation is prolonged during this period, fibroblasts do not decrease and collagen production continues, causing hypertrophic scars and keloids. The purpose of this Special Issue is to focus on inflammation and fibrosis and to explore their mechanisms.
Dr. Noriko Aramaki-Hattori
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