Special Issue "Evolving Landscape of DNA Repair in Cancer Therapy"
Deadline for manuscript submissions: 31 December 2023 | Viewed by 13134
Interests: pharmacotherapeutics; genome instability; DNA repair; neuro-oncology; system biology; biomarkers
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Cancer is fundamentally a disease of the genome that is reliant on a compromised DNA damage response (DDR) network to promote oncogenic transformation. Despite the need to undergo mutagenic changes, tumor cells are dependent on a repertoire of DNA repair mechanisms to maintain genome integrity and mediate resistance against genotoxic drugs. With the availability of high-throughput omics data, precision medicine can gain better insights into individual tumor profiles. By detecting vulnerabilities in the different DNA repair pathways, specific targeting can be implemented to eradicate tumor growth.
For this Special Issue, we are interested in featuring original research and review articles that focus on mammalian genome instability pathways and/or the links between DNA repair and cancer.
The articles that are suitable for this topic include:
- Identifying novel DNA repair factors involved in the sensing, signaling, and restoration of DNA damage.
- Developing single or combinational therapeutics that target DNA damage signaling and/or repair pathways.
- Advances in DNA damage response and/repair biomarkers for precision medicine.
- Intrinsic and acquired resistant profiles of DNA damage response in cancer.
- Methodology in defining new approaches to measure DNA repair and DNA damage.
Dr. Yi Chieh Lim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA damage response
- DNA repair
- genomic instability
- synthetic lethality
- precision medicine
- therapeutic resistance