Special Issue "The Role of Telomere and Telomerase in Human Disease"

Dear Colleagues,

Telomeres and telomerase have received an ever-increasing interest from the scientific community. The telomere/telomerase complex is the key element that determines unlimited replicative potential. Telomere shortening occurs at each round of cell division, accompanied by DNA synthesis, restricts cell proliferation and induces cell senescence and apoptosis in checkpoint-proficient normal somatic cells. Telomerase is a reverse transcriptase that maintains the length of telomere, endowing cells with the ability to proliferate indefinitely. Thus, the telomere/telomerase interaction plays a key role in the initiation and progression of diseases such as cancer and aging, making this complex an attractive therapeutic target.

In this Special Issue, entitled “The Role of Telomeres and Telomerase in Human Disease”, we welcome original studies and review articles presenting novel findings at the basic and translational levels of research in this field. Specifically, we are interested in the following issues: 1. the roles of shelterin and other proteins in telomere lengths regulation; 2. telomerase as an anticancer drug target; 3. extracurricular activities of telomerase; and 4. the role of telomerase in various diseases.

Dr. Orit Uziel
Guest Editor

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