DNA Repair: From Neuronal Development to Degeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 434

Special Issue Editor

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy
Interests: hippocampus; excitatory/inhibitory balance; development; plasticity

Special Issue Information

Dear Colleagues,

Recent studies have demonstrated that the proper development of cognitive abilities is also a consequence of the proper functioning of DNA double-strand breaks (DSBs) machinery. Exposure of mice to physiological learning paradigms in vivo is responsible for activity-induced DSBs restricted to loci in the genome, enriched for the early response genes, thus possibly impacting on synaptic function via epigenetic alterations. Furthermore, clinical reports describe developmental defects and increased hyperexcitability in subjects with genetic mutations against genes linked to the DNA repair pathways. This evidence indicates how changes in DNA repair proteins may affect brain developmental processes. In parallel, recent data established a connection between reduced DNA repair capacity and neurodegenerative conditions, which are profoundly characterized by defective cognitive abilities, as found in preclinical studies for Parkinson’s and Alzheimer’s diseases. Thus, the scope of this Special Issue is to highlight why and how DNA repair machinery is implicated in neurological and cognitive diseases, thus representing a new pathological substrate and potential therapeutic target for neurological states.

Dr. Flavia Antonucci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuronal development/degeneration
  • hippocampus
  • cortex
  • learning and memory
  • mice
  • humans
  • pharmacological approaches

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop