Special Issue "DNA Repair: From Neuronal Development to Degeneration"
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 368
Recent studies have demonstrated that the proper development of cognitive abilities is also a consequence of the proper functioning of DNA double-strand breaks (DSBs) machinery. Exposure of mice to physiological learning paradigms in vivo is responsible for activity-induced DSBs restricted to loci in the genome, enriched for the early response genes, thus possibly impacting on synaptic function via epigenetic alterations. Furthermore, clinical reports describe developmental defects and increased hyperexcitability in subjects with genetic mutations against genes linked to the DNA repair pathways. This evidence indicates how changes in DNA repair proteins may affect brain developmental processes. In parallel, recent data established a connection between reduced DNA repair capacity and neurodegenerative conditions, which are profoundly characterized by defective cognitive abilities, as found in preclinical studies for Parkinson’s and Alzheimer’s diseases. Thus, the scope of this Special Issue is to highlight why and how DNA repair machinery is implicated in neurological and cognitive diseases, thus representing a new pathological substrate and potential therapeutic target for neurological states.
Dr. Flavia Antonucci
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- neuronal development/degeneration
- learning and memory
- pharmacological approaches