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Special Issue "Molecular Mechanisms and Novel Therapies for Chronic Inflammatory Skin Diseases"

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A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 5546

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Special Issue Editors

Dr. Angelo Ruggiero

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Guest Editor

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoly, Italy
Interests: inflammatory skin diseases; psoriasis; hidradenitis; atopic dermatitis; acne and rosacea; infective diseases; ontological diseases in dermatology (including melanoma and nonmelanoma skin cancers); teledermatology; aesthetic medicine

Prof. Dr. Gabriella Fabbrocini

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Guest Editor

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoly, Italy
Interests: acne; inflammatory skin diseases (atopic dermatitis; hidradenitis; psoriasis); dermoscopy; melanoma; photodermatology and alopecia; dermocosmetological care of chemotherapy skin reaction “corpo ritrovato”
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Dr. Matteo Megna

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Special Issue Information

Dear Colleagues,

Recent major research advantages have led to notable advancements in the knowledge of the pathogenesis of inflammatory chronic skin diseases such as psoriasis, hidradenitis suppurativa, atopic dermatitis, and chronic urticaria. This has resulted in the development of new targeted therapies (biologic drugs, biosimilars, and small molecules), which have completely transformed the management of chronic inflammatory skin diseases.

The aim of this Special Issue is to collect high-value papers reporting interesting and novel data about molecular mechanisms behind chronic inflammatory skin diseases, as well as recent findings regarding currently available and future treatments, including data about experiences from real-life settings.

Dr. Angelo Ruggiero
Prof. Dr. Gabriella Fabbrocini
Dr. Matteo Megna
Guest Editors

Manuscript Submission Information

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Keywords

psoriasis
hidradenitis suppurativa
atopic dermatitis
chronic urticaria
biologic therapy
anti IL-23
anti IL-17
IL-23
IL-17
guselkumab
risankizumab
tildrakizumab
bimekizumab
Jak inhibitors
real-life experience
real-world evidence
molecular mechanisms
cytokines

Published Papers (4 papers)

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Research

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Open AccessArticle

Water Is an Active Element: A Randomized Double-Blind Controlled Clinical Trial Comparing Cutaneous Lipidomics in Consumers Drinking Two Different Bicarbonate-Calcic Waters (Medium-Mineral vs. Oligo-Mineral)

and

Biomedicines 2023, 11(4), 1036; https://doi.org/10.3390/biomedicines11041036 - 27 Mar 2023

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Abstract

Despite the well-known cutaneous beneficial effect of thermal water on the skin, no data exist regarding the potential biological effect of orally consumed water on healthy skin. Thus, in this single-center, double-blind, randomized controlled clinical trial conducted on age and menstrual cycle timing-matched healthy female volunteers (24 + 24) consuming water A (oligo-mineral) or water B (medium-mineral) for 1 month (T1), the cutaneous lipidomics were compared. Interestingly, only water A consumers had a statistically significant (p < 0.001) change in cutaneous lipidomics, with 66 lipids different (8 decreased and 58 increased). The cutaneous lipidomics of consumers of water A vs. water B were statistically different (p < 0.05). Twenty cutaneous lipids were necessary to predict the water type previously consumed (AUC ~70). Our study suggests that drinking oligo-mineral water may change skin biology and may influence the cutaneous barrier, so future dermatological clinical trials should also account for the water type consumed to avoid potential confounders. Full article

(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapies for Chronic Inflammatory Skin Diseases)

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Open AccessArticle

Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus

Shan Huang

Ya-Qin Tan

and

Gang Zhou

Biomedicines 2023, 11(3), 955; https://doi.org/10.3390/biomedicines11030955 - 20 Mar 2023

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Abstract

Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory disease. Interferon (IFN)-γ has been suggested to be vital for the OLP immune responses. A prominent innate-like lymphocyte subset, γδ T cells, span the innate–adaptive continuum and exert immune effector functions by producing a wide spectrum of cytokines, including IFN-γ. The involvement and mechanisms of γδ T cells in the pathogenesis of OLP remain obscure. The expression of γδ T cells in lesion tissues and in the peripheral blood of OLP patients was determined via flow cytometry and immunohistochemistry, respectively. Human leukocyte antigen-DR (HLA-DR), cluster of differentiation (CD) 69, Toll-like receptors (TLRs), natural killer group 2, member D (NKG2D) and IFN-γ were detected in γδ T cells of OLP patients using flow cytometry. Additionally, the involvement of stimulator of the interferon genes (STING)-TANK-binding kinase 1 (TBK1) pathway in γδ T cells was evaluated by multi-color immunofluorescence. Western blotting was employed to investigate the regulatory mechanisms of γδ T cells in OLP. γδ T cells were significantly upregulated in the lesion tissues, whereas their peripheral counterparts were downregulated in OLP patients. Meanwhile, increased frequencies of local CD69⁺ and NKG2D⁺ γδ T cells and peripheral HLA-DR⁺ and TLR4⁺ γδ T cells were detected in OLP. Furthermore, significant co-localization of STING and TBK1 was observed in the γδ T cells of OLP lesions. In addition, enhanced IFN-γ and interleukin (IL)-17A were positively associated with the activated STING-TBK1 pathway and γδ T cells in OLP. Taken together, the upregulated STING-TBK1 pathway in activated γδ T cells might participate in the regulation of immune responses in OLP. Full article

(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapies for Chronic Inflammatory Skin Diseases)

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Open AccessArticle

Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models

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Biomedicines 2022, 10(8), 1976; https://doi.org/10.3390/biomedicines10081976 - 15 Aug 2022

Cited by 1 | Viewed by 1506

Abstract

Patients with psoriasis tend to develop skin cancer, and the hyperproliferation of the epidermis is a histopathological hallmark of both psoriasis and cutaneous squamous cell carcinoma (SCC), indicating that they may share pathogenic mechanisms. Interleukin-17 (IL17) stimulates the proliferation of the epidermis, leading to psoriasis. Overexpression of Polo-like kinase 4 (PLK4), which controls centriole duplication, has been identified in SCC, which also shows the hyperproliferation of keratinocytes. To investigate the cooperation between IL17 signaling and centriole duplication in epidermal proliferation, we established psoriasis and skin papilloma models in wild type (WT), IL17 receptor A (T779A) knockin (Il17ra(T779A)-KI), and IL17 receptor C knockout (Il17rc-KO) mouse strains. Bioinformatics, Western blot, immunohistochemical staining, colony formation, and real-time PCR were used to determine the effect of IL17 signaling and centrinone on epithelial proliferation. In the psoriasis model, compared to WT and Il17ra(T779A)-KI, Il17rc-KO dramatically suppressed epidermal thickening. The proliferation of keratinocytes significantly decreased in this order from WT to Il17ra(T779A)-KI and Il17rc-KO mice. In the skin papilloma model, Il17ra(T779A)-KI significantly decreased tumor burden compared to the WT, while Il17rc-KO abolished papilloma development. However, centrinone, a selective inhibitor of PLK4, did not affect skin lesion formation in either model. Our data demonstrated that Il17ra(T779A)-KI and Il17rc-KO prevent the development of psoriasis and tumorigenesis in the skin, while the topical administration of centrinone does not have any effect. Full article

(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapies for Chronic Inflammatory Skin Diseases)

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Open AccessSystematic Review

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

Shazina Saeed

Priyadarshini Choudhury

Sultan Mohammed Kaleem

Smita R. Priyadarshini

Pradyumna Ku Sahoo

and

Shamimul Hasan

Biomedicines 2022, 10(11), 2964; https://doi.org/10.3390/biomedicines10112964 - 17 Nov 2022

Cited by 2 | Viewed by 2330

Abstract

Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects up to 2% of the general population, and typically presents with long-standing, non-responsive lesions, with episodes of exacerbation and remissions. The etiopathogenesis of OLP is still unclear, although, it has been postulated that it is most likely a T-cell-mediated condition of an unknown antigen. The treatment remains a challenge with no defined treatment strategy. Vitamin D has anti-inflammatory and immunomodulatory properties, along with its regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP. This systematic review aims to evaluate the therapeutic role of vitamin D in OLP treatment. We searched PubMed/MEDLINE, and Google scholar search engines for studies evaluating vitamin D as a treatment modality in OLP from January 2000 to August 2022. Articles were searched with the combination of Medical Subject Heading (MeSH) terms. A web platform for visualizing risk-of-bias assessment was used in this review, and descriptive statistics were calculated. Out of the seventeen retrieved studies, five articles meeting the inclusion criteria were considered in this systematic review. All the included studies demonstrated significant amelioration in the OLP symptoms in patients who were given vitamin D supplements as an adjuvant to the conventional steroid therapy and or placebo. This systematic review signifies the role of vitamin D as adjuvant therapy for OLP. However, more studies with larger sample size are required to validate these results. Full article

(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapies for Chronic Inflammatory Skin Diseases)

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