Special Issue "Chronic Kidney and Liver Disease: From Pathophysiology to Novel Therapeutic Approaches 2.0"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 9086
Interests: chronic kidney disease; non-alcoholic fatty liver disease; organ fibrosis; uremic toxins; bile acids; translational disease models; metabolic basis of disease
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The prevalence of chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) is on the rise, and it is expected that both diseases will become leading causes of death globally. CKD is defined by a long-standing loss of renal function and is associated with an increased risk of end-stage renal disease, cardiovascular disease and premature death. NAFLD is characterized by excessive fat accumulation in the liver, and it covers a spectrum of diseases, from simple steatosis to the more aggressive form of non-alcoholic steatohepatitis (NASH). Both CKD and NAFLD share risk factors that are increasingly prevalent, such as hypertension, diabetes and obesity. Consequently, both diseases frequently exist together. Yet, studies on the mechanistic link between CKD and NAFLD are sparse. To improve clinical care, a better understanding of the pathophysiological mechanisms that underlie the development and progression of both CKD and NAFLD is essential. For this Special Issue we welcome papers that focus on the pathogenesis of CKD, NAFLD and associated pathologies, in addition to papers detailing novel therapeutic targets and therapies. Papers that investigate the link between both diseases are especially welcomed.
Dr. Henricus A.M. Mutsaers
Manuscript Submission Information
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- chronic kidney disease
- non-alcoholic fatty liver disease
- non-alcoholic steatohepatitis
- renal fibrosis
- uremic toxins
- therapeutic targets