Special Issue "Photodynamic Biology"
Deadline for manuscript submissions: 31 January 2024 | Viewed by 1207
Interests: calcium oscillations; exocytosis; photodynamic therapy
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As defined originally, photodynamic action is dependent on oxygen. The extensively studied type II photodynamic action, involving the excited state molecular oxygen, the delta singlet oxygen (Δ1O2), modulates numerous of cellular functions. These include cell secretion, muscle contraction, cellular signaling, cell death and senescence, autophagy, gene transcription and translation, development, and protein oxidation. Photodynamic action has been studied extensively in large numbers of journals across multiple disciplines by researchers aiming for diagnosis, therapy, and to develop a research tool to tease apart specific cellular and molecular details. However, studies aiming to define mechanisms of action at the cellular and molecular levels are scattered in the literature.
This Special Issue aims to publish a series of clearly defined cases in which biological activity was clearly subject to photodynamic modulation. For example, for example modulation of all categories of function proteins, as defined by the International Union of Basic and Clinical Pharmacology (https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2021/178/S1): 1/ G protein coupled receptors; 2/ ionic channels; 3/ transporters; 4/ enzymes; 5/ catalytic receptors; 6/ nuclear hormone receptors; 7/ other functional proteins.
This Special Issue will seek to highlight biological or enzyme-catalyzed generation, reaction, and quenching of delta singlet oxygen of physiological and biochemical significance. Other potential research focuses could also be the light source (bioluminescence, for example) used to drive the photodynamic action, or the photosensitizer (the genetically encoded protein photosensitizers, for example) and their tagging patterns to the target of interest (TOI).
It is the hope of this Special Issue, run between Biomedicines and Cells to advance the field in a significant way, and to identify areas for future investigations in the next decade or beyond.
Contributions in the form original articles or reviews focused on a pivotal topic in the field of photodynamic biology are welcome.
Dr. Zong Jie Cui
Manuscript Submission Information
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- photodynamic action
- singlet oxygen
- cellular function
- functional proteins
- bioluminescent proteins as light sources