Special Issue "Photodynamic Biology"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 1207

Special Issue Editor

Institute of Cell Biology, Beijing Normal University, Beijing 100875, China
Interests: calcium oscillations; exocytosis; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As defined originally, photodynamic action is dependent on oxygen. The extensively studied type II photodynamic action, involving the excited state molecular oxygen, the delta singlet oxygen (Δ1O2), modulates numerous of cellular functions. These include cell secretion, muscle contraction, cellular signaling, cell death and senescence, autophagy, gene transcription and translation, development, and protein oxidation. Photodynamic action has been studied extensively in large numbers of journals across multiple disciplines by researchers aiming for diagnosis, therapy, and to develop a research tool to tease apart specific cellular and molecular details. However, studies aiming to define mechanisms of action at the cellular and molecular levels are scattered in the literature.

This Special Issue aims to publish a series of clearly defined cases in which biological activity was clearly subject to photodynamic modulation. For example, for example modulation of all categories of function proteins, as defined by the International Union of Basic and Clinical Pharmacology (https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2021/178/S1): 1/ G protein coupled receptors; 2/ ionic channels; 3/ transporters; 4/ enzymes; 5/ catalytic receptors; 6/ nuclear hormone receptors; 7/ other functional proteins.

This Special Issue will seek to highlight biological or enzyme-catalyzed generation, reaction, and quenching of delta singlet oxygen of physiological and biochemical significance. Other potential research focuses could also be the light source (bioluminescence, for example) used to drive the photodynamic action, or the photosensitizer (the genetically encoded protein photosensitizers, for example) and their tagging patterns to the target of interest (TOI).

It is the hope of this Special Issue, run between Biomedicines and Cells to advance the field in a significant way, and to identify areas for future investigations in the next decade or beyond.

Contributions in the form original articles or reviews focused on a pivotal topic in the field of photodynamic biology are welcome.

You may choose our Joint Special Issue in Cells.

Dr. Zong Jie Cui
Guest Editor

Manuscript Submission Information

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  • photodynamic action
  • autophagy
  • singlet oxygen
  • cellular function
  • functional proteins
  • photosensitizers
  • phototoxicity
  • bioluminescent proteins as light sources

Published Papers (1 paper)

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Photodynamic Activation of Cholecystokinin 1 Receptor Is Conserved in Mammalian and Avian Pancreatic Acini
Biomedicines 2023, 11(3), 885; https://doi.org/10.3390/biomedicines11030885 - 13 Mar 2023
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Cholecystokinin 1 receptor (CCK1R) is the only G protein coupled receptor that is activated in type II photodynamic action, but whether this is a property common to both mammalian and avian species is not known. In this work, pancreatic acini were isolated from [...] Read more.
Cholecystokinin 1 receptor (CCK1R) is the only G protein coupled receptor that is activated in type II photodynamic action, but whether this is a property common to both mammalian and avian species is not known. In this work, pancreatic acini were isolated from the rat, mouse, and Peking duck, and photodynamic CCK1R activation was examined. Isolated pancreatic acini were exposed to photosensitizer sulphonated aluminum phthalocyanine (SALPC) and photodynamic action elicited by a brief light-emitting diode (LED 675 nm) pulse (1.5 min); photodynamic CCK1R activation was assessed by Fura-2 fluorescent calcium imaging. Photodynamic action was found to induce persistent calcium oscillations in rat, mouse, and Peking duck pancreatic acini, with the sensitivity order of mouse > rat > Peking duck. Photodynamically-activated CCK1R could be inhibited reversibly by CCK1R antagonist devazepide (1 μM); photodynamic CCK1R activation was blocked by pre-incubation with 1O2 quencher Trolox C (300 µM). The sensitivity of photodynamic CCK1R activation was correlated with the increasing size of the disordered region in intracellular loop 3. These data suggest that photodynamic CCK1R activation is conserved in both mammalian and avian species, as evidenced by the presence of the photodynamic activation motif “YFM” in transmembrane domain 3. Full article
(This article belongs to the Special Issue Photodynamic Biology)
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