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Special Issue "Molecular Regulators and Therapeutic Strategies for Obesity and Diabetes"
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 7999
Special Issue Editors
Interests: food bioactives; nutritional immunology; nutrition and cancer; nutritional and metabolic diseases; obesity-related metabolic and immune disorders
E-Mail Website1 Website2
Interests: bioactive peptides; food proteins; multifuncionality; digestion; bioavailability; inflammation-associated diseases; chemopreventive activity; peptidomics; antioxidant activity
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Special Issue Information
Obesity is considered a critical issue and a global health problem worldwide. Accumulating evidence shows that obesity increases the risk of noncommunicable diseases, such as cardiovascular disease, osteoarthritis, cancer, metabolic dysfunction, and type 2 diabetes mellitus (T2DM). During adiposity, adipocytes behave as an endocrine organ releasing mediators such as adipokines, cytokines, and chemokines to recruit multiple kinds of immune cells infiltrated into the adipose tissues, resulting in the development of these chronic disorders. Pancreas of diabetic patients is unable to produce enough insulin to maintain normal blood glucose levels or show resistance to the effect of insulin, thereby resulting in hyperglycemia. Moreover, these patients develop severe symptoms and higher mortality rates during pathogenic infection.
Epidemiological and experimental studies have evidenced that people with overweight or obesity tend to develop T2DM, named diabesity. The potential mechanisms implied in the pathogenesis of T2DM include abnormal lipid profile and metabolites, immune dysregulation, oxidative stress, alterations in the insulin and glucose uptake signaling, mitochondrial dysfunction, and metabolic disorder. One of the best strategies to prevent diabetes is lifestyle modification, including physical activity and a healthy diet, and maintaining appropriate body weight. Moreover, the inclusion in the daily intake of antidiabetic compounds derived from natural sources and foods, has been recognized as a promising alternative because of their safety and lack of adverse side effects. Thus, the search for new sources of antidiabetic compounds and the demonstration of their beneficial effects is an area of great interest for the prevention/management of this global epidemic issue.
This Special Issue will include original research and in-depth reviews with the most recent insights into topics related to the (1) molecular and biochemical mechanisms of obesity and diabetes; (2) metabolic syndrome; (3) immunomodulation for obesity and diabetes; (4) and new natural preventive/therapeutic strategies for treating obesity and diabetes, and their associated disorders.
Dr. Chia-Chien Hsieh
Dr. Blanca Hernández-Ledesma
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- metabolic syndrome
- insulin resistance
- inflammatory cytokines
- glucose utilization
- lipid metabolism
- natural or food compounds