Protein Misfolding and Functional Impairment in Neurodegenerative Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 170

Special Issue Editors


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Guest Editor
Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, Greece
Interests: bioinformatics; computational biomedicine; drug discovery, molecular analysis, biomarkers; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Informatics, Ionian University, Corfu, Greece
Interests: health analytics; decision support systems; biomedical engineering; biomedical informatics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, Greece
Interests: bioinformatics; mathematical modeling; big data; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Proteins play an integral role in almost every aspect of cellular processes. The problem of protein folding is a major concern in modern biology. Neurodegenerative diseases often involve the misfolding and aggregation of specific proteins, which leads to the formation of abnormal and harmful structures. While misfolded disease proteins primarily exert their effects through toxic gain-of-function and/or dominant-negative effects, instances of loss-of-function effects have also been recorded. Significant experimental efforts have been undertaken to comprehend the fundamental principles of folding and to unravel the mechanisms underlying misfolding and related diseases. Furthermore, computational techniques such as homology modeling and ab initio methods are widely applied in this direction. Recent progress in AI models such as AlphaFold and RoseTTAFold has significantly transformed the study of protein folding. Understanding the fundamentals of protein quality control and the relationships between structure and function can be instrumental in comprehending the mechanisms and pathological roles of disordered proteins.

This Special Issue intent to present recent studies that contribute to our understanding of protein misfolding, as well as on the role of functional impermeant in neurodegenerative diseases. Original research articles and reviews on molecular mechanisms, experimental and computational approaches for studying folding issues are expected and welcome.

Dr. Marios Krokidis
Dr. Themis Exarchos
Prof. Dr. Panayiotis Vlamos
Guest Editors

Manuscript Submission Information

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Keywords

  • protein misfolding
  • chaperones
  • energy landscape
  • neurodegenerative diseases
  • amyloidogenesis
  • intrinsically disordered proteins
  • structure prediction algorithms
  • bioinformatics
  • molecular dynamic simulations

Published Papers

This special issue is now open for submission.
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