Special Issue "Non-coding RNAs in Health and Disease 2.0"
Deadline for manuscript submissions: 29 February 2024 | Viewed by 5428
Interests: cancer cell biology; microRNAs; pediatric brain tumors; metabolic diseases
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The idea that genetic information travelling towards proteins has long represented the “central dogma” of molecular biology. However, proteins are encoded only from the 2% of the human genome, while the widest part is represented by non-coding transcriptome. Non-coding RNAs (nc-RNAs) indeed comprise the largest part of the transcriptional production of the human genome, playing pivotal roles in both health and disease processes. Some of them, such as microRNAs and circular RNAs (circRNAs), are highly conserved across species; others, such as long non-coding RNAs (lnc-RNAs), lack conservation. Nc-RNAs are especially involved in regulatory functions; moreover, they can interact with each other to regulate stability or abundance. These interactions are of the utmost importance in the regulation of many different cellular programs. As a result, their dysregulation, as well as the perturbation of their interactions, may have striking consequences. In addition, nc-RNAs have also recently been described in the extracellular compartment, therefore inferring that they mediate cell-to-cell communication and act as disease-specific diagnostic, prognostic and treatment response biomarkers.
This Special Issue aims to focus on the role of the different species of nc-RNAs in controlling pivotal biological mechanisms, such as gene expression and developmental pathways, and on analyzing their dysregulation in the context of many different human diseases, spanning from metabolic, neurological and cardiovascular diseases to cancer. Moreover, it will concentrate on the possibility of using these molecules as biomarkers, with the potential to use liquid biopsies in modern precision medicine. Original research articles and comprehensive reviews are both welcomed here.
Dr. Giuseppina Catanzaro
Manuscript Submission Information
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- non-coding RNAs
- cellular pathways
- developmental pathways
- gene expression
- metabolic diseases
- neurological diseases
- cardiovascular diseases
- liquid biopsy