Molecular Insights into Retinal Degeneration
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 181
Special Issue Editor
2. Department of Ophthalmology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan
Interests: oxidative stress; inflammation; autophagy; mitochondrial dynamics; endoplasmic reticulum stress; calcium channels; cell migration; retinal cell death modalities; retinal degeneration
Special Issue Information
Dear Colleagues,
Retinal degeneration is a progressive condition that leads to vision loss. Recent research has focused on understanding the molecular mechanisms that contribute to this condition. Oxidative stress and inflammation are significant factors that can trigger the death of photoreceptor cells in the retina. The visual cycle, which is regulated by a group of enzymes and transporters, converts light into electrical signals that the brain receives. Mutations in these genes can impair the visual cycle and cause toxic byproducts to accumulate, leading to the death of photoreceptor cells. Gene therapy is a promising approach to treat this degenerative condition by restoring the function of defective genes and preventing the death of photoreceptor cells. However, it is still in the experimental stage and requires further testing before it can be considered as a viable treatment option. The molecular mechanisms underlying retinal degeneration are complex and multifaceted. This Special Issue will advance our understanding of these mechanisms and contribute to the development of new therapies that hold promise for the treatment of this condition.
Dr. Chi-Ming Chan
Guest Editor
Manuscript Submission Information
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Keywords
- retinal degeneration
- oxidative stress
- inflammation
- visual cycle
- gene therapy
- photoreceptor
- cell death
