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Biomedicines
Special Issues
Rheological Properties in Diseases and Diagnosis: Cells, Spheroids and Tissues
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Rheological Properties in Diseases and Diagnosis: Cells, Spheroids and Tissues

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2844

Special Issue Editors

Dr. Joanna Zemła

E-Mail Website
Guest Editor
Department of Biophysical Microstructures, Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, Poland
Interests: biomechanics of cells; rheology of cells and tissues; physics of cancer; AFM; protein adsorption; bacterial adhesion
Dr. Carmela Rianna

E-Mail Website
Guest Editor
NanoBioPhysics and Medical Physics, Institute of Applied Physics, Eberhard Karls University of Tübingen, Auf der Morgenstelle 10, 72076 Tübingen, Germany
Interests: cell mechanics; biophysics of cancer cells; cancer metastases; cell confinement; cell motility; AFM

Special Issue Information

Dear Colleagues,

It is our pleasure to announce a Special Issue of Biomedicines that is devoted to the rheological properties of biological materials. The rheology of tissues plays an important role in many key physiological processes, such as cell migration, wound healing, cancer metastasis, and morphogenesis, and dictates the deformation response of the tissue with respect to both external and internal forcing. It has been demonstrated that the ability to accurately measure the mechanical properties of biological objects enables many diagnostic and research applications to be performed; in the presence of disease (not only cancers), the rheological properties of cells and tissues change, which can be used as a marker to discriminate between different biological conditions. Many techniques, such as atomic force microscopy-based rheological measurements (AFM-R), rheometer, optical tweezers, pipette aspiration techniques, and real-time flow cytometry (RT-FC), have been employed to describe the mechanical properties of cells and tissues subjected to tension, compression, shear or strain.  The observed mechanical response of cell aggregates under deformation has been found to be elastic, viscoelastic, viscous, or plastic, depending on the forces applied and the time scale of the observation.

The topics of interest for this Special Issue on "Rheological Properties in Diseases and Diagnosis: Cells, Spheroids and Tissues" include, but are not limited to, the following:

  • Rheological properties in cancer;
  • Biophysical models in rheology;
  • Rheological properties of biological tissues;
  • Viscoelastic properties of healthy and diseased tissues;
  • Rheological properties of spheroids and organoids;
  • Rheology in neuromuscular diseases and therapy;
  • Shear rheology;
  • Blood rheology.

Considering your distinguished contribution in this currently substantial research field, we would like to cordially invite you to submit an article to this Special Issue. Full research papers and review articles are welcome.

We are looking forward to receiving your contribution.

Dr. Joanna Zemła
Dr. Carmela Rianna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rheological properties in cancer
  • biophysical models in rheology
  • rheological properties of biological tissues
  • viscoelastic properties of healthy and diseased tissues
  • rheological properties of spheroids and organoids
  • rheology in neuromuscular diseases and therapy
  • shear rheology
  • blood rheology

Published Papers (2 papers)

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Research

14 pages, 3435 KiB  
Article
Interdependence of Rheological and Biochemical Parameters of Blood in a Group of Patients with Clinically Silent Multifocal Vascular Cerebral Lesions
by Anna Marcinkowska-Gapińska, Izabela Siemieniak, Weronika Kawałkiewicz, Olgierd Stieler, Dorota Hojan-Jezierska and Leszek Kubisz
Biomedicines 2023, 11(7), 2063; https://doi.org/10.3390/biomedicines11072063 - 22 Jul 2023
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Abstract
Background: Hemorheology is a field of science which often becomes interesting to researchers studying impairments related to blood flow disturbances. Clinically silent vascular cerebral lesions (CSVCLs) are considered a problem of great importance in neurology. Objective: This work aimed to analyze the interdependencies [...] Read more.
Background: Hemorheology is a field of science which often becomes interesting to researchers studying impairments related to blood flow disturbances. Clinically silent vascular cerebral lesions (CSVCLs) are considered a problem of great importance in neurology. Objective: This work aimed to analyze the interdependencies of the rheological and biochemical parameters of the blood. Methods: The group of patients included persons with clinically silent multifocal vascular cerebral lesions diagnosed using neuroimaging. The control group had no symptoms in the central nervous system (CNS). We analyzed hemorheological profiles in 69 patients with CSVCLs diagnosed via magnetic resonance imaging (MR) or 64-row computer tomography measurements. Rheological data were acquired using a rotary-oscillating rheometer, the Contraves LS-40, an instrument dedicated to blood viscosity measurements. For each sample, the hematocrit value was measured using the standard method. Analysis of erythrocytes’ aggregability and deformability was performed using the rheological model of Quemada. Biochemical tests of blood were also performed. Results: The results of rheological and biochemical studies were compared with those obtained in the control group. Special attention was paid to the correlation analysis of rheological and biochemical parameters. Conclusions: Such correlations were found, e.g., between the red cells’ deformability and the fibrinogen level. The results improve our understanding of blood flow hemodynamics by analyzing the shear-dependent behavior of the aggregation and deformability of red blood cells. Full article
(This article belongs to the Special Issue Rheological Properties in Diseases and Diagnosis: Cells, Spheroids and Tissues)
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10 pages, 518 KiB  
Article
Sputum-Rheology-Based Strategy for Guiding Azithromycin Prescription in COPD Patients with Frequent Exacerbations: A Randomized, Controlled Study (“COPD CARhE”)
by Jeremy Charriot, Maeva Zysman, Laurent Guilleminault, Mathilde Volpato, Aurelie Fort-Petit, Isabelle Vachier, Jeremy Patarin, Carey Suehs, Engi Ahmed, Nicolas Molinari and Arnaud Bourdin
Biomedicines 2023, 11(3), 740; https://doi.org/10.3390/biomedicines11030740 - 01 Mar 2023
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Abstract
(1) Background: We have previously shown that sputum rheology can discriminate between patients with COPD and other muco-obstructive lung diseases, and that it is correlated with mucin content and sputum eosinophilia. We now hypothesize that it could be a more-accurate guide than clinical [...] Read more.
(1) Background: We have previously shown that sputum rheology can discriminate between patients with COPD and other muco-obstructive lung diseases, and that it is correlated with mucin content and sputum eosinophilia. We now hypothesize that it could be a more-accurate guide than clinical evaluation for the prescription of azithromycin to prevent exacerbations of COPD and to reduce exposure to antibiotics; (2) Methods: “COPD CaRhe” is a multicentric, randomized, controlled trial comparing outcomes in two parallel arms (36 vs. 36 patients). Patients will be recruited in the university hospitals of Montpellier, Bordeaux, and Toulouse, in France, and they should have a diagnosis of COPD with frequent exacerbations (≥3/year). Enrollment will occur during a routine visit to a respiratory department, and follow-up visits will occur every 3 months for a period of 1 year. At each visit, a 3-month prescription of azithromycin will be provided to those patients who obtain a score of <70 on the Cough and Sputum Assessment Questionnaire (CASA-Q) or a critical stress score of σc > 39 on a rheological assessment of sputum, depending upon their randomization group. The primary outcome will be the number of exacerbations of COPD; (3) Discussion: By using sputum rheology, the COPD CaRhe study may provide clinicians with an objective biomarker to guide the prescription of azithromycin while reducing the cumulative exposure to macrolides. Full article
(This article belongs to the Special Issue Rheological Properties in Diseases and Diagnosis: Cells, Spheroids and Tissues)
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