p53 Signaling in Cancer Progression and Therapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 2490
Special Issue Editor
Interests: p53 protein; regulation of p53 expression; cancer development; translation initiation mechanisms; structure and function of the 5' - terminus of RNAs
Special Issue Information
Dear Colleagues,
The p53 protein is one of gatekeepers in the cell which plays a pivotal role as a transcriptional factor involved in cell cycle regulation and tumorigenesis prevention. Under normal conditions the level of p53 protein is kept low due to interaction with E3 ubiquitin ligase Mdm2. In the presence of stress factors p53 is phosphorylated to prevent the interaction with Mdm2 and as a consequence p53 signaling pathway is activated. It eventually leads to rebuild cell homeostasis. Mutations in TP53 gene cause production of faulty p53 protein which loses its ability to govern the efficient cell response to stress. This, in many cases, results in cancer development. It has been pointed that mutations in TP53 gene are observed in approximately 50-60% of cancers including breast, lung, colon, prostate, liver and bladder. Since effectiveness of p53 signaling pathway is crucial to suppress tumor development mutated p53 protein is one of a major target in anti-cancer therapies. Restoration of ability of p53 to act properly seems to be an attractive alternative approach in treatment of cancer patients.
In this Special Issue we will discuss the multi-functions of p53 protein; its involvement in stress response and tumor suppression. Hopefully, this Special Issue will provide fascinating insight into the p53 signaling pathway and how mutant of p53 is able to change the cell fate. This Special Issue will also be a great opportunity to examine potential therapeutic approaches based on targeting p53 mutants to restore proper acting of p53 signaling network.
Dr. Agata Świa̧tkowska
Guest Editor
Manuscript Submission Information
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Keywords
- p53 protein
- p53 signaling pathway
- Mdm2-p53 axe
- TP53 gene
- p53 hotspot mutations
- cell cycle
- apoptosis
- tumor progression
- anti-cancer therapy
