Dear Colleagues,

Iron status influences a vast array of cellular processes.  Iron imbalance or dysregulation can have adverse, clinically-significant  effects on gene regulation, enzyme activities, mitochondrial function, stress response and even cell viability.  Absolute or functional iron deficiency can lead to morbidity, impairs neurobehavioural development in early life, predisposes to immune dysfunction, and is associated with adverse outcomes in patients with cancer, heart failure or those undergoing surgery.  At the other end of the spectrum, iron has been associated with inflammatory processes, oxidative stress, mitochondrial dysfunction and ferroptosis.  Some of these and related cellular events have implications for neurodegenerative, cardiovascular, pulmonary, hepatic and other disorders.  The expanding knowledge of the involvement of iron in cellular function has encouraged exciting avenues of research that are increasing our understanding of the pathogenic mechanisms of some common diseases, and may pave the way for interventions that would alleviate those conditions or improve clinical outcomes.

It gives me great pleasure to invite researchers who are studying cellular processes and mechanisms of disease in which iron plays a significant role to submit their original research or review papers for this special issue of Biomedicines.  The aim of this special issue is to offer emerging knowledge or overviews of the pathophysiological mechanisms through which iron imbalance may bring about clinical effects.  Research involving clinical studies or the use of human cells are especially, but not exclusively, welcome.

Dr. Alireza Morovat
Guest Editor

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• iron deficiency
• iron overload
• pathophysiology
• inflammation
• organ disorders
• cancer
• neurodegenerative disease
• immune function
• therapy