Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "Thalassemia Research: Focus on Novel Molecular Insights and Clinical Perspectives"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 20 July 2023 | Viewed by 15170
Special Issue Editors
Interests: thalassemia; leukemia; gene expression; transcriptional factors; mitochondria function; oxidative stress
Interests: hemoglobinopathies; blood disorders; bone marrow diseases
Special Issue Information
The thalassemia syndromes are among the most common human monogenic disorders worldwide, with a remarkably high incidence in the Mediterranean basin, part of Sub-Saharan Africa, the Middle East, the Indian subcontinent, and Southeast Asia. However, as the result of massive population movements, and given the chronicity of the disease and the high cost of life-long treatments, they are also becoming an important public health burden in many other European and American countries.
Historically, since the early, pioneering studies, thalassemia research has always provided inspiring lessons for discovering the complex processes and the variety of the structural elements involved in the regulation of gene expression as well as for exploring the molecular bases and the inheritance mechanisms of other human diseases. However, despite the impressive body of knowledge gathered in these decades, there is still a need for further studies in molecular genetics and clinical management that could contribute to define more effective prevention programs and support the development of novel drugs and more successful and affordable gene-therapy strategies.
To achieve these challenging targets, more in-depth knowledge is required with particular regard to the contribution of modifying factors on the clinical heterogeneity of thalassemias, the genetic control of fetal hemoglobin, the identification of novel therapeutic targets, and the advances in clinical practice leading to increase life expectancy and improve quality of life.
The purpose of this Special Issue is thus to provide novel insights and perspectives into this continually evolving topic that in the future could lead to a definitive and affordable cure for these disorders. We also hope that the research described herein can be a source of inspiration to the readers for further studies in this fascinating and not yet fully explored field.
Dr. Michela Grosso
Dr. Alexandros Makis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- globin gene switching
- fetal hemoglobin
- genetic modifiers
- gene therapy
- clinical management
- transcriptional factors
- gene silencing
- genome editing
- mutation detection