Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Applications
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 57471
Special Issue Editors
Interests: neurodegeneration; disease emchanisms; therapy; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Interests: neuroscience; vascular diseases; clinical medicine
Interests: Neuroscience; neurophysiology; Calcium signalling; oxidative stress
Special Issue Information
Dear Colleagues,
Neurodegenerative disease is a group of heterogeneous neural disorders, characterized by the progressive dysfunction and death of neurons. Most neurodegenerative diseases are complex diseases, associated with both genetic and environmental factors. Major neuron death pathways include apoptosis, necroptosis, pyroptosis and ferroptosis. Accumulated data from in vitro and in vivo studies suggest that oxidative stress, endoplasmic reticulum (ER) stress and inflammation contribute to neuron loss. Patient inducible potent stem (iPS) cell-derived neurons are excellent in vitro models for elucidating disease mechanisms and provide a platform for drug screening. A number of small chemicals and natural products have shown therapeutic potential for neurodegenerative diseases, while cell replacement and gene therapy have shown promise for certain types of condition. However, a more comprehensive understanding of the pathogenesis and the development of new strategies for their treatment are urgently needed.
The purpose of this special issue is to collect recent developments in the elucidation of the pathophysiology of different neurodegenerative diseases and in the appraisal of therapeutic options. It provides an opportunity for researchers in the field to submit their invaluable studies. We welcome original research papers, review articles and perspectives. We look forward to receiving your contribution.
Keywords
- neurodegeneration
- cell death
- oxidative stress
- inflammation
- antioxidants
- natural products
- regeneration
- stem cells