Cell Transport in Health and Disease

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1783

Special Issue Editor

Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, China
Interests: tumor microenvironment; transporter protein; exosome; cancer biology; cancer therapy resistance; bioinformatics; mathematical model

Special Issue Information

Dear Colleagues,

The regulation and coordination of cell transport processes are critical for cellular function and overall organismal health. Altered cell transport plays a significant role in disease development, progression and response to therapy, especially in cancer. The abnormal transport of cancer cells affects many functions, such as nutrient uptake, ion channel and pumps, drug efflux, etc., which closely relates with the tumor microenvironment. Hence, it is crucial to explore the interaction between the tumor microenvironment and cancer cell transport to understand the underlying mechanism and provide novel strategies for targeted cancer therapies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Cell transport;
  • Cancer;
  • Tumor microenvironment;
  • Cell–ECM interaction;
  • Exosome;
  • Immunity.

We look forward to receiving your contributions.

Dr. Yuan Li
Guest Editor

Manuscript Submission Information

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Keywords

  • cell transport
  • cancer
  • tumor microenvironment
  • cell–ECM interaction
  • exosome
  • immunity

Published Papers (1 paper)

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Review

13 pages, 2860 KiB  
Review
Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
by Camille Menaceur, Océane Dusailly, Fabien Gosselet, Laurence Fenart and Julien Saint-Pol
Biology 2023, 12(12), 1530; https://doi.org/10.3390/biology12121530 - 15 Dec 2023
Viewed by 1444
Abstract
Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses. This vesicular trafficking also enables the cell to engage in secretory processes for the [...] Read more.
Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses. This vesicular trafficking also enables the cell to engage in secretory processes for the elimination of waste products or for the emission of intercellular communication vectors such as cytokines, chemokines and extracellular vesicles. Ras-related proteins (Rab) and their effector(s) are of crucial importance in all of these processes, and mutations/alterations to them have serious pathophysiological consequences. This review presents a non-exhaustive overview of the role of the major Rab involved in vesicular trafficking, with particular emphasis on their involvement in the biogenesis and secretion of extracellular vesicles, and on the role of Rab27 in various pathophysiological processes. Therefore, Rab and their effector(s) are central therapeutic targets, given their involvement in vesicular trafficking and their importance for cell physiology. Full article
(This article belongs to the Special Issue Cell Transport in Health and Disease)
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