Mechanisms of Oncogenic Self-Renewal in Hematopoietic Stem Cells
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: closed (1 August 2023) | Viewed by 371
Special Issue Editor
Special Issue Information
Dear Colleagues,
A key characteristic of hematopoietic stem cells is the ability to self-renew. The balance between self-renewal and differentiation in hematopoietic stem cells is controlled by several genes and signaling pathways. A tight balance is critical for sustaining the functional integrity of hematopoiesis, which prevents HSC exhaustion or hematologic malignancies such as leukemia. Accumulating evidence suggests that most leukemias are initiated by rare leukemic stem cells. While some signaling pathways are essential for the self-renewal of normal hematopoietic stem cells, there may be distinct ones in leukemia stem cells. The dysregulation of self-renewal in leukemia stem cells is crucial for relapse after chemotherapy. Emerging therapeutic agents targeting aberrant self-renewal pathways present significant clinical potential. Therefore, further insights into the mechanism of self-renewal in hematopoietic stem cells are needed to identify new potential key genes and pathways to enhance our understanding regarding self-renewal and differentiation in leukemic stem cells and improve the development of therapeutic agents for cancer therapy.
This Special Issue aims to provide an overview on current developments in the field of hematopoietic stem cells’ self-renewal. We welcome submissions of research articles and reviews that relate to self-renewal and differentiation in hematopoietic stem cells and leukemia stem cells, including topics in the field of basic and translational research as well as diagnostic applications.
Prof. Dr. Xiaona You
Guest Editor
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Keywords
- self-renewal
- hematopoietic stem cells
- differentiation
- therapeutic agents
- leukemogenesis
