Cancer Stem Cells Biology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 244
Special Issue Editors
Interests: cancer stem
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The first modern evidence for a role of stem cells in cancer came in 1994 with a study of human acute myeloid Leukemia, in which an AML-initiating cell population was identified from AML patients by transplantation into severe combined immune-deficient (SCID) mice. CSCs are defined by the ability to self-renew and their proliferative potential, and they also produce differentiated cells. Asymmetric cell division achieves both tasks, as one progeny retains the stem cell’s (SC) identity and the other undergoes rounds of cell division and subsequent post-mitotic differentiation. To date, there are no standard criteria for classifying CSCs; therefore, it has not been possible to definitively define the proportion of the CSC subpopulation within a tumor, or the relevance of CSCs to clinical outcomes. Several markers have been investigated, such as CD44, CD24, CD29, CD90, CD133, epithelial-specific antigen (ESA), and aldehyde dehydrogenase1 (ALDH1); however, a specific marker has not been identified because the expression of CSC surface markers is actually tissue-type-specific, even tumor-subtype-specific. Progress in identifying the CSC-specific surface markers, understanding the regulation of CSC tumorigenic capacity, and linking CSCs to clinical outcomes will be helpful to drive the therapeutic application of targeting CSCs into the clinic.
Dr. Beatrice Aramini
Dr. Valentina Masciale
Guest Editors
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Keywords
- stem cells
- cancer
- CSCs (cancer stem cells)
- surface markers
- therapeutic application
