Growth Regulation and Tumor Biology in Drosophila

Dear Colleagues,

Controlled growth is a prerequisite for organ size regulation, while uninhibited growth results in tumor formation. Drosophila, as a model system, has contributed significantly to the current understanding of the genetic basis of growth regulation and tumor development. The identification of evolutionarily conserved tumor suppressors, such as members of the Hippo pathway, in Drosophila is an example of a key discovery that was later shown to be conserved in higher organisms. The deregulation of the Hippo pathway is associated with multiple human cancers. Studies on Drosophila have uncovered the molecular underpinnings of tumor initiation, progression, and metastasis. Drosophila has provided unprecedented insights into the roles of key cellular processes, such as tissue homeostasis, innate immunity, autophagy, inter-organ signaling, and metabolism, among many others, in tumor development. Cell competition, which involves the elimination of abnormal cells, was first discovered in Drosophila and has been shown to play a role in tumor suppression as well as expansion. Interestingly, the model system is now being successfully used to screen small molecules and biologics to restrict tumor growth.

To further our understanding of the underlying mechanisms regulating growth and tumorigenesis, using Drosophila as a model system, we are inviting original research papers or review articles to a Special Issue on “Growth regulation and tumor biology in Drosophila”. The manuscript can be submitted on the following subtopics:

1. Genetic basis of growth regulation during development and tumorigenesis.
2. Role of cellular activities, such as autophagy and the Warburg effect, in tumor development.
3. Role of the immune system and tumor microenvironment in tumor biology.
4. Cell competition in the suppression or growth of tumors.
5. Antitumor drug screening using Drosophila as a model system.

Dr. Amit Kumar
Dr. Satya Surbhi
Dr. Anjali Bajpai
Prof. Dr. Madhuri Kango-Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Drosophila
• growth regulation
• tumor biology
• metastasis
• oncogene
• tumor suppressor gene
• drug discovery