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Biology
Special Issues
Cardiovascular and Metabolic Disorders in Diabetes
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Cardiovascular and Metabolic Disorders in Diabetes

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1289

Special Issue Editors

Prof. Dr. Bee K. Tan

E-Mail Website
Guest Editor
Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK
Interests: pregnancy; biomarker; GDM; preeclampsia
Special Issues, Collections and Topics in MDPI journals
Dr. Jiamiao Hu

E-Mail Website
Guest Editor
1. College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China
2. Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, China
Interests: non-thermal sterilization; photodynamic treatment; low-voltage electrostatic field treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes is a metabolic disease characterized by high blood glucose levels. According to global statistics on diabetes, approximately 463 million people suffered from diabetes in 2019, and this number is expected to increase to 700 million by 2045. Diabetes is often accompanied by a range of complications such as cardiovascular diseases and metabolic disorders. In fact, the likelihood of a diabetic patient developing heart disease is 2 to 4 times higher than a non-diabetic patient. Metabolic disorders associated with diabetes, such as obesity, dyslipidemia, and insulin resistance, further increase the risk of developing cardiovascular disease. Therefore, understanding the pathogenesis of cardiovascular and metabolic disorders in diabetes is crucial in the field of healthcare. Particularly, exploring and identifying the possible mechanisms underlying diabetes-related complications could provide useful information for the development of prevention and treatment strategies.

In order to gain a deeper understanding of the cardiovascular and metabolic disorders in diabetes, we invite researchers to submit cutting-edge original and review articles on the topic of “Cardiovascular and Metabolic Disorders in Diabetes”. Original research articles, timely reviews, and short communications are welcome. This Special Issue aims to contribute to the much-needed knowledge regarding reducing the risk of cardiovascular and metabolic complications in diabetic patients, promoting the development of novel drug therapies and appropriate interventions, which will provide valuable insight and useful information for the scientific community, ranging from basic to clinical researchers.

Prof. Dr. Bee K. Tan
Dr. Jiamiao Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • cardiovascular diseases
  • metabolic disorders
  • obesity
  • dyslipidemia
  • physiological mechanism
  • insulin resistance

Published Papers (1 paper)

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Research

14 pages, 5275 KiB  
Article
RNA-seq Analysis Reveals Potential Synergic Effects of Acetate and Cold Exposure on Interscapular Brown Adipose Tissue in Mice
by Hongtao Ou, Qingyan Chen, Zhongjing Lin, Yang Yang, Peixin Wang, Natthida Sriboonvorakul and Shaoling Lin
Biology 2023, 12(10), 1285; https://doi.org/10.3390/biology12101285 - 26 Sep 2023
Viewed by 1029
Abstract
Brown adipose tissue (BAT) exhibits remarkable morphological and functional plasticity in response to environmental (e.g., cold exposure) and nutrient (e.g., high-fat diet) stimuli. Notably, a number of studies have showed that acetate, the main fermentation product of dietary fiber in gut, profoundly influences [...] Read more.
Brown adipose tissue (BAT) exhibits remarkable morphological and functional plasticity in response to environmental (e.g., cold exposure) and nutrient (e.g., high-fat diet) stimuli. Notably, a number of studies have showed that acetate, the main fermentation product of dietary fiber in gut, profoundly influences the differentiation and activity of BAT. However, the potential synergic or antagonistic effects of acetate and cold exposure on BAT have not been well examined. In the present study, the C57BL/6J mice were treated with acetate at the systemic level before a short period of cold exposure. Physiological parameters including body weight, blood glucose, and Respiratory Exchange Ratio (RER) were monitored, and thermal imaging of body surface temperature was captured. Moreover, the transcriptome profiles of interscapular BAT were also determined and analyzed afterwards. The obtained results showed that acetate treatment prior to cold exposure could alter the gene expression profile, as evidenced by significant differential clusters between the two groups. GO analysis and KEGG analysis further identified differentially expressed genes being mainly enriched for a number of biological terms and pathways related to lipid metabolism and brown adipose activity such as “G-protein-coupled receptor activity”, “cAMP metabolic process”, “PPAR signaling pathway”, and “FoxO signaling pathway”. GSEA analysis further suggested that activation status of key pathways including “PPAR signaling pathway” and “TCA cycle” were altered upon acetate treatment. Taken together, our study identified the potential synergistic effect of acetic acid with cold exposure on BAT, which highlighted the positive dietary and therapeutic aspects of acetate. Full article
(This article belongs to the Special Issue Cardiovascular and Metabolic Disorders in Diabetes)
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