The Biological Impact of Endocrine Disrupting Chemicals

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2580

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Department of Biological, Geological and Environmental Sciences, University of Catania, Via Androne 81, 95124 Catania, Italy
Interests: marine biology; vertebrate and non-vertebrate species; models for toxicological testing; biomarkers; immunohistochemistry; electron microscopy; emerging contaminants; nanoparticles
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Special Issue Information

Dear Colleagues,

Endocrine disrupting chemicals (EDCs) are compounds that alter the structure and function of the endocrine system and may be contributing to disorders of the reproductive, metabolic, neuroendocrine, and other complex systems. Some ECDs being slow to break-down in the environment, persevere in the environment for a long time and have a resilient propensity to bioaccumulate in the food chain. That characteristic makes them potentially hazardous over time for wildlife and humans. For this reason ecotoxicological research is crucial to support risk assessment and management of ECDs due to of global environmental change. The purpose of this Special Issue is to select and publish high-quality and impactful research and review articles on ECDs effects in wildlife and human populations. In particular, original and high-quality research related to in vivo, in vitro, and in silico studies, including both field and laboratory approaches.

Dr. Maria Violetta Brundo
Guest Editor

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Keywords

  • endocrine disrupting chemicals
  • emerging contaminants
  • bioaccumulation
  • biomarkers
  • in vivo, in vitro and in silico test
  • environmental pollution and monitoring
  • risk assessment and management
  • sea and freshwater species
  • terrestrial species

Published Papers (1 paper)

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Research

24 pages, 2833 KiB  
Article
Cumulus Cell Transcriptome after Cumulus-Oocyte Complex Exposure to Nanomolar Cadmium in an In Vitro Animal Model of Prepubertal and Adult Age
by Nicola Antonio Martino, Ernesto Picardi, Elena Ciani, Anna Maria D’Erchia, Luisa Bogliolo, Federica Ariu, Antonella Mastrorocco, Letizia Temerario, Luigi Mansi, Valeria Palumbo, Graziano Pesole and Maria Elena Dell’Aquila
Biology 2023, 12(2), 249; https://doi.org/10.3390/biology12020249 - 4 Feb 2023
Cited by 1 | Viewed by 2267
Abstract
Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cumulus cells (CCs). This study analysed the transcriptomic profile of CCs of cumulus-oocyte complexes (COCs) from adult and prepubertal sheep, exposed to Cd nanomolar concentration during in vitro maturation. In [...] Read more.
Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cumulus cells (CCs). This study analysed the transcriptomic profile of CCs of cumulus-oocyte complexes (COCs) from adult and prepubertal sheep, exposed to Cd nanomolar concentration during in vitro maturation. In both age-groups, CCs of matured oocytes underwent RNA-seq, data analysis and validation. Differentially expressed genes (DEGs) were identified in adult (n = 99 DEGs) and prepubertal (n = 18 DEGs) CCs upon Cd exposure. Transcriptomes of adult CCs clustered separately between Cd-exposed and control samples, whereas prepubertal ones did not as observed by Principal Component Analysis. The transcriptomic signature of Cd-induced CC toxicity was identified by gene annotation and literature search. Genes associated with previous studies on ovarian functions and/or Cd effects were confirmed and new genes were identified, thus implementing the knowledge on their involvement in such processes. Enrichment and validation analysis showed that, in adult CCs, Cd acted as endocrine disruptor on DEGs involved in hormone biosynthesis, cumulus expansion, regulation of cell signalling, growth and differentiation and oocyte maturation, whereas in prepubertal CCs, Cd affected DEGs involved in CC development and viability and CC-oocyte communications. In conclusion, these DEGs could be used as valuable non-invasive biomarkers for oocyte competence. Full article
(This article belongs to the Special Issue The Biological Impact of Endocrine Disrupting Chemicals)
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