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Biology
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Cardiovascular Disease Risk Factors and Atherosclerosis Biomarkers
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Cardiovascular Disease Risk Factors and Atherosclerosis Biomarkers

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2873

Special Issue Editor

Dr. Xiangyu Zhang

E-Mail Website
Guest Editor
Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO 63110, USA
Interests: cardiovascular disease; atherosclerosis; inflammation; macrophages; autophagy; lysosome; metabolism; cell death

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) is the leading cause of death worldwide. Atherosclerosis plays a critical role in the majority of mortalities due to coronary artery disease and myocardial infarction. Therefore, as the usual cause of cardiovascular disease, atherosclerosis is a main target of clinical therapy for health protection. Previous studies have revealed multiple factors affecting CVDs, including total cholesterol, high-density lipoprotein cholesterol, blood pressure, glucose resistance, and smoking. Each risk factor could lead to regulation in several distinctive signaling pathways and downstream dysfunction, while different risk factors may have crosstalk and corresponding combination effects. Therefore, it is vital to consider all of these factors when developing therapeutic strategies. Meanwhile, classical risk factors should also be included. 

The Special Issue welcomes the submission of original research and review articles focusing on signaling pathways and metabolic dysfunction regulated by the risk factors of atherosclerosis and correlating cardiovascular disease. In addition, research on new technologies employed for studying atherosclerosis biomarker identification and prediction which will help us to understand the underlying mechanism of CVD is also welcome. This Special Issue will enlighten readers about new discoveries, advances, and developments in atherosclerosis and related CVDs.

Dr. Xiangyu Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • atherosclerosis
  • risk factors
  • dietary nutrients
  • metabolism
  • inflammation
  • signaling pathway
  • autophagy
  • apoptosis
  • biomarkers

Published Papers (2 papers)

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Research

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16 pages, 4423 KiB  
Article
The Interplay between Atherosclerosis and Cancer: Breast Cancer Cells Increase the Expression of Endothelial Cell Adhesion Markers
by Alessandro Scalia, Lesly Doumani, Nadège Kindt, Fabrice Journé, Anne Trelcat and Stéphane Carlier
Biology 2023, 12(7), 896; https://doi.org/10.3390/biology12070896 - 22 Jun 2023
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Abstract
Cardiovascular diseases are the leading causes of death worldwide, closely followed by cancer. To investigate the impact of breast cancer cell lines (SKBR3, MCF-7, and MDA-MB-231) on endothelial cell adhesion, a blended medium containing 30% breast-cancer-conditioned medium was prepared. This medium was then [...] Read more.
Cardiovascular diseases are the leading causes of death worldwide, closely followed by cancer. To investigate the impact of breast cancer cell lines (SKBR3, MCF-7, and MDA-MB-231) on endothelial cell adhesion, a blended medium containing 30% breast-cancer-conditioned medium was prepared. This medium was then exposed to human umbilical vein endothelial cells (HUVECs) and monocytes (THP-1) for 48 h. Homemade oxidized low-density lipoproteins (oxLDL) were optionally added to the blended medium. Immunofluorescence was performed to assess the expression of E-selectin, connexin-43, and ICAM-1 on HUVECs, as well as LOX-1, CD36, and CD162 on THP-1. Additionally, unoxidized LDL was exposed to the three breast cancer cell lines for 48 h, and the formation of oxLDL was quantified. Our results revealed an upregulation of all six adhesion markers involved in the initiation of atherosclerosis when HUVECs and THP-1 were exposed to the breast-cancer-conditioned medium. Furthermore, this expression was further increased by exposure to oxLDL. We also observed a significant elevation in oxLDL levels when LDL was exposed to breast cancer cells. In conclusion, our findings successfully demonstrate an increased LDL oxidation in the presence of breast cancer cells, accompanied by an augmented expression of receptors involved in atherosclerosis initiation. These findings shed new light on the clinically observed interplay between atherosclerosis and cancer. Full article
(This article belongs to the Special Issue Cardiovascular Disease Risk Factors and Atherosclerosis Biomarkers)
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Review

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10 pages, 16945 KiB  
Review
Are Panoramic Images a Good Tool to Detect Calcified Carotid Atheroma? A Systematic Review
by María Prados-Privado, Javier García Villalón, Antonio Blázquez Torres, Carlos Hugo Martínez-Martínez, Juan Carlos Prados-Frutos and Carlos Ivorra
Biology 2022, 11(11), 1684; https://doi.org/10.3390/biology11111684 - 21 Nov 2022
Viewed by 1292
Abstract
To investigate the reliability of panoramic dental images to detect calcified carotid atheroma, electronic databases (PubMed, IEEE/Xplore and Embase) were searched. Outcomes included cerebrovascular disease events, cardiovascular disease events, patient previous diseases, and combined endpoints. Risk of bias was evaluated using the Newcastle-Ottawa [...] Read more.
To investigate the reliability of panoramic dental images to detect calcified carotid atheroma, electronic databases (PubMed, IEEE/Xplore and Embase) were searched. Outcomes included cerebrovascular disease events, cardiovascular disease events, patient previous diseases, and combined endpoints. Risk of bias was evaluated using the Newcastle-Ottawa Scale. Hence, 15 studies were selected from 507 potential manuscripts. Five studies had a low risk of bias, while the remaining nine studies were found to have a moderate risk. Heterogeneous results were obtained but showed that patients with risk factors, such as obesity, diabetes mellitus, hypertension, and smoking, and with calcified carotid atheroma on panoramic images, have a higher prevalence than healthy patients. The evidence in the literature was found to be equivocal. However, the findings of this systematic review exhibit that panoramic radiographs can be used for dental diagnosis and treatment planning, as well as to detect calcified carotid artery atheroma. Full article
(This article belongs to the Special Issue Cardiovascular Disease Risk Factors and Atherosclerosis Biomarkers)
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