Redox Enzymes in Tumorigenesis and Cancer Progression

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2049

Special Issue Editor

1. Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, 1095 Veterans Dr, Lexington, KY 40508, USA
2. Markey Cancer Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
Interests: reactive oxygen species; redox enzymes; tumorigenesis cancer

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS), physiological products of many metabolic processes, are oxygen-containing molecules that are highly unstable and reactive to macromolecules. The rapid production of ROS also occurs in infections, inflammation and tissue damage caused by exposure to various pathogens or environmental factors such as contaminants, toxicants, radiation, etc. The maintenance of certain levels of ROS is critical not only for the host to defend against microorganisms, but also for the full activation of various intracellular signaling cascades. However, excessive levels of ROS cause extensive damage to host DNA, RNA, proteins and lipids, an aspect considered to be one of the fundamental mechanisms promoting cancer development. It has been well documented that antioxidant enzymes are critical for the maintenance of redox homeostasis, but whether and how they contribute to the process of tumorigenesis and the malignancy of cancer cells remains to be elucidated. In addition, understanding the maintenance of the redox balance and molecular pathways that distinguish cancer from normal cells or tissue could be utilized to develop promising therapeutics for the treatment of cancer in patients.

I am pleased to invite you to contribute your expertise and research to this Special Issue aimed at increasing the impact of redox studies in cancer research, as well as expanding the knowledge surrounding antioxidants and their potential value in cancer treatments. In this Special Issue, original research articles and reviews are welcome. Research arears may include, but are not limited to, the following:

(1) Fundamental mechanisms of redox maintenance in normal or cancer cells;
(2) Understanding the damage caused by oxidative stress and mechanistic insights;
(3) Antioxidants or redox enzymes and their involvement in cell signaling, cell transformation and tumorigenesis;
(4) Antioxidants or redox enzymes and their contribution to the malignancy of cancer cells;
(5) Enzymatic and nonenzymatic antioxidant players in cancer-related therapeutics;
(6) Any other redox-related, basic or translational studies in cancer biology.

Dr. Qiou Wei
Guest Editor

Manuscript Submission Information

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Keywords

  • reactive oxygen species
  • reactive nitrogen species
  • redox homeostasis
  • antioxidant
  • tumorigenesis
  • carcinogenesis
  • cell invasion
  • metastasis
  • chemotherapy

Published Papers (1 paper)

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Review

23 pages, 1837 KiB  
Review
The Role of Peroxiredoxins in Cancer Development
by Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani and Qiou Wei
Biology 2023, 12(5), 666; https://doi.org/10.3390/biology12050666 - 28 Apr 2023
Cited by 4 | Viewed by 1767
Abstract
Peroxiredoxins (Prxs) are antioxidant enzymes with ubiquitous expression in human tissues. Prxs are expressed in archaea, bacteria, and eukaryota, often in multiple isoforms. Because of their abundant expression in different cellular organelles and extraordinary sensitivity to H2O2, Prxs are [...] Read more.
Peroxiredoxins (Prxs) are antioxidant enzymes with ubiquitous expression in human tissues. Prxs are expressed in archaea, bacteria, and eukaryota, often in multiple isoforms. Because of their abundant expression in different cellular organelles and extraordinary sensitivity to H2O2, Prxs are among the first defenses against oxidative stress. Prxs undergo reversible oxidation to disulfides, and some family members perform chaperone or phospholipase functions upon further oxidation. Prxs are upregulated in cancer cells. Research has suggested that Prxs can function as tumor promoters in various cancers. The major objective of this review is to summarize novel findings regarding the roles of Prxs in common cancer types. Prxs have been shown to influence differentiation of inflammatory cells and fibroblasts, remodeling of extracellular matrix, and regulation of stemness. Since aggressive cancer cells have higher intracellular levels of ROS that they can utilize to proliferate and metastasize compared to normal cells, it is critical that we understand the regulation and functions of primary antioxidants such as Prxs. These small but mighty proteins could prove to be key for improving cancer therapeutics and patient survival. Full article
(This article belongs to the Special Issue Redox Enzymes in Tumorigenesis and Cancer Progression)
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