Lysosome and Cell Death in Human Health
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: closed (18 November 2023) | Viewed by 169
Special Issue Editor
Special Issue Information
Dear Colleagues,
Lysosomes are the main degradative organelle of eukaryotic cells and thus important for both cellular metabolism and the removal of damaged or unwanted organelles and proteins. Material to be degraded can be delivered through different forms of autophagy, phagocytosis or endocytosis. Lysosomes also play a key role in cell death, which can be initiated or amplified by the release of degradative lysosomal enzymes into the surrounding cell. In addition, lysosomes are also important for cell signaling, secretion, and immunity.
Well-functioning lysosomes are thus essential for maintaining cellular and organismal integrity and homeostasis. Disruptions in lysosomal function and/or loss of lysosomal membrane integrity can have devastating consequences. Over the years, lysosomes have been shown to be involved in numerous diseases, e.g., lysosomal storage diseases, stroke and neurodegenerative diseases, autoimmune diseases, cancers, cardiovascular diseases, and infections. This also makes lysosomes important therapeutic targets.
The function of lysosomes, their links to cell death and their role in disease and therapy will be the topics covered by this Special Issue.
Dr. Sonja Aits
Guest Editor
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Keywords
- lysosome
- autophagy
- cell death
- lysosomal storage diseases
- neurodegeneration
- immunity
- cancer
- stroke
- cardiovascular disease
- targeted therapies
