Cancer at High Altitude: Mechanistic Insights and Targeted Therapies

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 260

Special Issue Editors

Institute of Veterinary Physiology, University of Zurich, 8057 Zurich, Switzerland
Interests: hypoxia; high altitude; cancer; angiogenesis; metastasis; metabolism
1. Institute of Veterinary Physiology, University of Zurich, 8057 Zurich, Switzerland
2. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
Interests: cancer biology; translational medicine; hypoxia, erythropoietin; myoglo-bin; cardiovascular diseases; metabolic syndrome; obesity; diabetes mellites; high altitude; angiogenesis; metastasis

Special Issue Information

Dear Colleagues,

Cancer mortality is reduced in humans who live at high altitudes. Although highlanders are exposed to permanent hypoxic stress, the physiological adaptation (or acclimatization) mainly driven by hypoxia may explain why highlanders are better protected against a wide variety of cancer types than those living at low altitudes. However, socioeconomic factors and a more active lifestyle may also contribute to reduced cancer mortality. The exact underlying mechanism(s) are currently not known. Unraveling these mechanisms may provide insights into cancer-biological processes that may help to develop new treatment approaches. 

We are pleased to invite you to submit original research papers or reviews on all aspects of cancer biology at high altitude to this Special Issue. Additionally, the scope should not be too broad or too narrow. 

This Special Issue aims to address relevant epidemiological, physiological, and cell biological aspects of cancer, metastasis, and cancer-associated comorbidities at high altitude. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: high-altitude-induced changes in tumor hypoxia and angiogenesis, metastasis, metabolism, drug response, anemia of cancer, or the tumor microenvironment, including immune cell infiltration in tumors.

We look forward to receiving your contributions. 

Dr. Markus Thiersch
Dr. Mostafa A. Aboouf
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypoxia
  • high altitude
  • cancer
  • angiogenesis
  • metastasis
  • metabolism
  • cancer biology
  • translational medicine

Published Papers

There is no accepted submissions to this special issue at this moment.
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