Radiation-Induced Genotoxicity and Health Effects
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2552
2. National Innovation Center of Radiation Application, Beijing 102413, China
Interests: ionizing radiation; DNA damage response; DNA damage repair; radiation mutagenesis; radiation sensitization
Interests: radiation resistance; radiosensitivity; DNA damage response; DNA damage repair; genomic instability
Interests: radiocarcinogenesis; radiomutagenesis; DNA damage response; risk assessment
Interests: DNA damage response; DNA damage repair; chromosomal aberration; reactive oxygen species; nutrition and lifestyle
Interests: radiogenotoxicity; radioadaptation; radiocarcinogenesis; nutrition and lifestyle; proactive radiation protection
Special Issues, Collections and Topics in MDPI journals
Radiation exposure is a major public health concern, with potential health consequences. Radiation-induced genotoxicity is a critical scientific question in the field of radiation biology. Radiation can cause genotoxic damage to the genetic material (DNA) of living organisms and is particularly known for its ability to generate different types of DNA damage, including DNA single-/double-strand breaks, base alterations, and cross-links, among others. Unrepaired or improperly repaired DNA damage can lead to chromosomal aberrations, cell death, and mutations. The severity of radiation-induced genotoxicity depends on physical and biological parameters, such as the quality of radiation (radiation type and LET); quantity of radiation (dose and dose rate); duration of exposure; and biological status of the target (cell cycle, cell type, and types of tissues and organs; age, sex, developmental conditions, genetic background, and psychological and lifestyle factors of the individual).
Radiation-induced genotoxicity can lead to different health effects, including deterministic effects (such as acute radiation syndrome) and stochastic effects (such as cancer), mainly depending on the radiation dose and dose rate. In addition, the application of radiation in medicine, agriculture, and other fields has been greatly developed. For example, the ability of radiation to induce cell death, mutations, and chromosomal aberrations, has been utilized in radiation therapy, radiation mutation breeding, and radiation risk assessment, respectively. With the rapid development of radiation technology, novel ways to study radiation biology, using accelerated particle beams, multi-ion beams, particle–photon mixed beams, etc., have emerged in addition to traditional X-ray and gamma-ray. Therefore, it is crucial to further understand the genotoxicity and health effects caused by various types of radiation to provide a theoretical basis for the development of radiation biology and its applications.
This Special Issue will provide a platform for researchers to share their latest achievements and new insights into radiation-induced genotoxicity and health effects. Original research studies, review articles, and perspectives are encouraged. Some radiation-induced genotoxicity and health effects relevant to the topics of particular interest may include, but are not limited to, the following:
- Radiation-induced DNA damage and repair;
- Radiation-induced epigenetic modifications;
- Effects from exposure to radiation at a low dose or low dose rate;
- Tissue reactions to ionizing radiation;
- Radiation teratogenesis, mutagenesis, and carcinogenesis;
- Radiation dosimetry;
- Effects from concurrent exposure to radiation and other factors;
- Epidemiological effects of radiation exposure;
- Radiation-induced heritable effects and transgenerational effects;
- Radiation countermeasures;
- Radiation risk assessment;
- Radiation applications.
We look forward to receiving your contributions.
Prof. Dr. Liqiu Ma
Prof. Dr. Chang Xu
Dr. Yi Shang
Dr. Takanori Katsube
Dr. Bing Wang
Manuscript Submission Information
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- risk assessment
- DNA damage
- DNA repair
- deterministic effects
- stochastic effects
- epidemiological effects