Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.0
4.2
Journals
Biology
Special Issues
Extracellular Vesicles: Multifaceted Biological Nanoparticles in Health and Disease (Volume...
share announcement

Extracellular Vesicles: Multifaceted Biological Nanoparticles in Health and Disease (Volume II)

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 2508

Special Issue Editor

Dr. Meena Kumari

E-Mail Website
Guest Editor
College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Interests: mRNA stability and alcohol addiction; exosomes and their role in differentiation and addiction to drugs of abuse
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is part of a series with Special Issue "Extracellular Vesicles: Multifaceted Biological Nanoparticles in Health and Disease”.

Since the initial discovery of dendritic cell exosomes as effective cancer biotherapies, cell–cell communication via exosomes has highlighted their impact on stem cell differentiation during development, maintenance of cellular homeostasis as well as various diseases, including cancer. Understanding the role of extracellular vesicles in physiological and pathophysiological processes can harness their potential in clinical medicine. The significant presence of exosomes in most body fluids and easy accessibility has garnered much interest in biomarker discovery as well as a means to improve diagnostics and monitor disease progression. The present Special Issue on extracellular vesicles is focused on a variety of topics, including mechanisms of subcellular origin and release of extracellular vesicles; in vivo targeting of fluorescently labeled extracellular vesicles; targeted loading of macromolecules into extracellular vesicles and unloading in recipient cells; and intercellular roles of extracellular vesicles in development, cell function, and diseases. Original research manuscripts, review manuscripts, brief reports, and opinions/insights are invited for publication in this Issue.

Dr. Meena Kumari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles and exosomes
  • isolation and characterization
  • biological activity in development, differentiation, health and disease
  • therapeutic applications

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

26 pages, 2360 KiB  
Review
Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles
by Prashant Kumar, Darshan Mehta and John J. Bissler
Biology 2023, 12(9), 1178; https://doi.org/10.3390/biology12091178 - 29 Aug 2023
Viewed by 1506
Abstract
Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous cellular functions such as tumor growth, metastasis, immunosuppression, and angiogenesis. They can be used as a drug delivery platform because they can protect drugs [...] Read more.
Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous cellular functions such as tumor growth, metastasis, immunosuppression, and angiogenesis. They can be used as a drug delivery platform because they can protect drugs from degradation and target specific cells or tissues. With the advancement in the technologies and methods in EV research, EV-therapeutics are one of the fast-growing domains in the human health sector. Therapeutic translation of EVs in clinics requires assessing the quality, safety, and efficacy of the EVs, in which pharmacokinetics is very crucial. We report here the application of physiologically based pharmacokinetic (PBPK) modeling as a principal tool for the prediction of absorption, distribution, metabolism, and excretion of EVs. To create a PBPK model of EVs, researchers would need to gather data on the size, shape, and composition of the EVs, as well as the physiological processes that affect their behavior in the body. The PBPK model would then be used to predict the pharmacokinetics of drugs delivered via EVs, such as the rate at which the drug is absorbed and distributed throughout the body, the rate at which it is metabolized and eliminated, and the maximum concentration of the drug in the body. This information can be used to optimize the design of EV-based drug delivery systems, including the size and composition of the EVs, the route of administration, and the dose of the drug. There has not been any dedicated review article that describes the PBPK modeling of EV. This review provides an overview of the absorption, distribution, metabolism, and excretion (ADME) phenomena of EVs. In addition, we will briefly describe the different computer-based modeling approaches that may help in the future of EV-based therapeutic research. Full article
(This article belongs to the Special Issue Extracellular Vesicles: Multifaceted Biological Nanoparticles in Health and Disease (Volume II))
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop