Morphological and Molecular Advances in Colorectal and Lung Cancers Biology

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1815

Special Issue Editor


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Guest Editor
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Section of Human Anatomy, Electron Microscopy Unit, Laboratory "Pietro M. Motta", Faculty of Pharmacy and Medicine, University of Rome La Sapienza, Via Alfonso Borelli 50, 00161 Rome, Italy
Interests: scanning electron microscopy; transmission electron microscopy

Special Issue Information

Dear Colleagues,

In terms of incidence and death, lung and colorectal cancer are in first place and are recognized worldwide as tremendously threatening diseases. Although they are located in completely different organs and differ in various characteristics, they share some common features, especially regarding their molecular mutational profile. Despite the impressive body of knowledge gathered in recent decades on these cancers, there is still a need for further studies that could contribute to defining: biomarkers, experimental models for drug therapy, and gene-therapy strategies.

The purpose of this Special Issue is to collect papers reporting new insights into colorectal and lung cancer biology by different approaches. We welcome original papers related to:

   (1) Morphology

Morphological biomarkers (from microscopy imaging to clinical imaging) needed to provide new diagnostic and prognostic tools.

   (2) Molecular (OMICs)

Identification of cancer-specific molecular features and shared molecular features between colorectal and lung cancers, the results will improve the cancers biology knowledge and will be used as the basis to find biomarkers and develop new therapies.

   (3) Innovative Experimental models

Development of organoids culture procedures, and organoid use as tools for innovative drug therapies.

   (4) Artificial intelligence

Application of artificial intelligence in pathology slide interpretation as a new tool for fast and large screening procedures.

We aim to provide novel insights and perspectives into this continually evolving topic that in the future could lead to a definitive and affordable cure for these cancers.

Dr. Michela Relucenti
Guest Editor

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Keywords

  • colorectal cancer
  • lung cancer
  • morphology
  • molecular

Published Papers (1 paper)

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Research

16 pages, 1475 KiB  
Article
Direct-Current Electrical Field Stimulation of Patient-Derived Colorectal Cancer Cells
by Falko Lange, Katrin Porath, Tina Sellmann, Anne Einsle, Robert Jaster, Michael Linnebacher, Rüdiger Köhling and Timo Kirschstein
Biology 2023, 12(7), 1032; https://doi.org/10.3390/biology12071032 - 22 Jul 2023
Viewed by 1151
Abstract
Several cues for a directional migration of colorectal cancer cells were identified as being crucial in tumor progression. However, galvanotaxis, the directional migration in direct-current electrical fields, has not been investigated so far. Therefore, we asked whether direct-current electrical fields could be used [...] Read more.
Several cues for a directional migration of colorectal cancer cells were identified as being crucial in tumor progression. However, galvanotaxis, the directional migration in direct-current electrical fields, has not been investigated so far. Therefore, we asked whether direct-current electrical fields could be used to mobilize colorectal cancer cells along field vectors. For this purpose, five patient-derived low-passage cell lines were exposed to field strengths of 150–250 V/m in vitro, and migration along the field vectors was investigated. To further study the role of voltage-gated calcium channels on galvanotaxis and intracellular signaling pathways that are associated with migration of colorectal cancer cells, the cultures were exposed to selective inhibitors. In three out of five colorectal cancer cell lines, we found a preferred cathodal migration. The cellular integrity of the cells was not impaired by exposure of the cells to the selected field strengths. Galvanotaxis was sensitive to inhibition of voltage-gated calcium channels. Furthermore, signaling pathways such as AKT and MEK, but not STAT3, were also found to contribute to galvanotaxis in our in vitro model system. Overall, we identify electrical fields as an important contributor to the directional migration of colorectal cancer cells. Full article
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