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Bioengineering
Special Issues
Application of Cells, Bio-Nanovesicles and Bio-Nanoparticles for Regenerative Therapy
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Application of Cells, Bio-Nanovesicles and Bio-Nanoparticles for Regenerative Therapy

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5721

Special Issue Editor

Dr. Prakash Gangadaran

E-Mail Website
Guest Editor
Department of Biomedical Science & Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea
Interests: oral cancer; extracellular vesicles; molecular and nuclear imaging; wound healing; cell-based cancer therapies and tyrosine kinase inhibitor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cells with therapeutic uses have attracted a lot of interest in the field of regenerative medicine. The native origin of cell therapies is not yet fully understood, and more research is needed to allow their therapeutic potential to be fully exploited. Cells for use in therapy can be obtained in vitro from different tissue sources and show heterogeneity regarding their fate, phenotype, and functions. Thus, it has become necessary to establish new methods and create standards for comparing these distinct populations of cells that have uses in therapy. As therapeutic cells’ functions are mainly supported by paracrine pathways that consist of several regulatory factors (such as cytokines and growth factors) and nucleic acids that can be secreted or packaged into extracellular vesicles, cellular communication can be induced by the exosomal contents, consisting of proteins, DNA, and RNA cargo (especially microRNA and long non-coding RNA), as well as metabolomes. The role and composition of exosomal contents vary depending on the source of the exosome. The identification of these factors may open the way for the use of cell-free therapeutic tools to repair and treat injured tissues.

The aim of this Special Issue is to highlight the recent developments regarding the therapeutic properties and mechanisms of cell-based and cell-free therapy. Original research, systematic reviews, and review articles are welcome.

Dr. Prakash Gangadaran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

• Cell therapy
• MSC
• Extracellular vesicles
• Exosomes
• Cell-derived bionanovesicles
• Nanoparticles
• Platelet-rich plasma
• Bone regeneration
• Wound healing
• Ischemia
• Tissue engineering
• Regenerative diseases.

Published Papers (2 papers)

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12 pages, 4972 KiB  
Article
Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect
by Uma P. Nair, Ravindra Shivamurthy, Raghavendra Reddy Nagate, Saurabh Chaturvedi, Saad M. Al-Qahtani, Mohammad Al Magbol, Shankar T. Gokhale, Shreyas Tikare and Mudita Chaturvedi
Bioengineering 2022, 9(11), 602; https://doi.org/10.3390/bioengineering9110602 - 22 Oct 2022
Cited by 13 | Viewed by 2517
Abstract
Background: Periodontal diseases lead to bone loss, crestal defects and even loss of the tooth, which also further makes it difficult to replace the tooth. Autogenous bone grafts are considered the gold standard in bone regenerative procedures. This study aimed to compare [...] Read more.
Background: Periodontal diseases lead to bone loss, crestal defects and even loss of the tooth, which also further makes it difficult to replace the tooth. Autogenous bone grafts are considered the gold standard in bone regenerative procedures. This study aimed to compare and evaluate the bone regenerative effects of i-PRF (Injectable- Platelet-rich fibrin) with a bone graft and a bone graft alone in mandibular grade II furcation defects over a period of 9 months. Method: This was a comparative study of 12 participants, who were randomly selected and grouped into two groups: test and control. Following phase I therapy, both groups were subjected to open flap debridement. In the test group, after debridement, a nano-hydroxyapatite bone graft mixed with i-PRF was inserted, whereas in the control group only a nano-hydroxyapatite bone graft was inserted. The clinical parameters such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), clinical attachment level (CAL), horizontal probing depth (HPD) and vertical probing depth (VPD) were recorded at baseline, 3 months, 6 months and 9 months following the surgery. The bone area fill (BAF) was assessed using intraoral periapical radiographs (IOPARs) taken at baseline and 9 months after surgery. Results: At the baseline, there was no statistically significant difference between the tested parameters. After 9 months all the clinical parameters, PI, GI, PPD, CAL, HPD and VPD as well as radiographic bone fill showed a significant increase in both the groups (p < 0.05) (PI-TGr; CGr–VPD—3.5 ± 0.54 to 0.66 ± 0.51; 3.3 ± 0.81 to 2 ± 0.63/BAF—2.9 ± 0.88 to 5.6 ± 1.10; 3.4 ± 1.39 to 3.9 ± 1.4). On comparison the test group showed better results for each clinical parameter. Conclusion: The results showed increased improvement in clinical conditions in both groups, although better results were seen in the group where i-PRF with a nano-HA bone graft was used in the furcation defect. Full article
(This article belongs to the Special Issue Application of Cells, Bio-Nanovesicles and Bio-Nanoparticles for Regenerative Therapy)
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11 pages, 648 KiB  
Systematic Review
Current Role of Intra-Articular Injections of Platelet-Rich Plasma in Adhesive Capsulitis of Shoulder: A Systematic Review
by Bushu Harna, Vijay Gupta, Shivali Arya, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Madhan Jeyaraman, Prakash Gangadaran, Manish Khanna, Chae Moon Hong and Byeong-Cheol Ahn
Bioengineering 2023, 10(1), 21; https://doi.org/10.3390/bioengineering10010021 - 22 Dec 2022
Cited by 3 | Viewed by 2735
Abstract
Adhesive capsulitis shoulder is a common problem of patients presenting with shoulder pain and disability. The approach to such patients includes a variety of modalities. This systematic review evaluates the efficacy of intra-articular injections of platelet-rich plasma (PRP) in the treatment. A literature [...] Read more.
Adhesive capsulitis shoulder is a common problem of patients presenting with shoulder pain and disability. The approach to such patients includes a variety of modalities. This systematic review evaluates the efficacy of intra-articular injections of platelet-rich plasma (PRP) in the treatment. A literature search was performed between January 2010 and 30 May 2022. MeSH terms used were ‘Platelet-rich plasma’ OR ‘PRP’ AND ‘Frozen shoulder’ OR ‘Adhesive capsulitis shoulder’ OR ‘Periarthritis shoulder’. The search included published articles in the English language involving human subjects. Studies evaluating other types of shoulder disorders, in vitro studies, review articles, animal-model studies, and pre-clinical trials were excluded. The data regarding study characteristics, efficacy, and safety outcomes were analyzed. A total of 11 studies with 347 patients over 10 years were finally included in this review. Most publications were in 2019 and 2020, mostly from India. This review included seven comparative studies, three case series, and one case report. In seven studies, a single intra-articular PRP injection was administered, whereas in the rest of the studies two or multiple injections were given. Only one study demonstrated an equivocal efficacy of PRP and steroid intra-articular injection. The rest all depicted better clinical and functional outcomes with the PRP injection. Only one study compared the outcomes of hydro-dissection treatment in adhesive capsulitis with the intra-articular PRP injection. The rest all either examined PRP alone or compared it with the steroid intra-articular injection. None of the studies showed any major side effects. The intra-articular injections of PRP in the management of adhesive capsulitis of the shoulder provide a new treatment approach. Further studies are required to ascertain the efficacy and safety of the PRP intraarticular injection as a management alternative in adhesive capsulitis. Full article
(This article belongs to the Special Issue Application of Cells, Bio-Nanovesicles and Bio-Nanoparticles for Regenerative Therapy)
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