Life Science and Technology Research in Huazhong University of Science and Technology: Commemorating the University’s 70th Anniversary

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2572

Special Issue Editors

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: structure and function of membrane receptors; regulatory mechanism of membrane receptors on aging and aging related diseases
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: microfluidics; micro/nanoscale biomedical analysis and biomedical photonics; organ-on-a-chip; in vitro diagnosis
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: nanomedicine; nano drug delivery systems; nanodiagnostics; biomedical nanomaterials
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: functional molecular materials; polymers based biological; chemical sensors; nanophamarceutics

Special Issue Information

Dear Colleagues,

Huazhong University of Science and Technology is celebrating its 70th anniversary in 2022. The College of Life Science and Technology is one of the biggest and most important colleges in the university and has made great achievements in the past decades. Founded in 1980, the college is now composed of five departments: Biomedical Engineering, Biological Science, Biotechnology, Bioinformatics and Systems Biology, and Nanomedicine and Biopharmaceuticals. In the fourth round of the national disciplinary assessment in 2017, the college’s Biomedical Engineering program ranked 1st in China while the Biology program ranked 9th.

In recognition of these achievements, Bioengineering is planning a dedicated Special Issue entitled “Life Science and Technology in Huazhong University of Science and Technology: Commemorating the University’s 70th Anniversary”. This Special Issue will publish high-quality full research articles or comprehensive literature reviews in the broad scope of biology and biomedical engineering. We would like to invite you to contribute an original research paper or a comprehensive review article on a trendy or hot topic for peer review and possible publication.

Prof. Dr. Jianfeng Liu
Prof. Dr. Bifeng Liu
Prof. Dr. Xiangliang Yang
Prof. Dr. Liang Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

16 pages, 4362 KiB  
Article
Effects and Prognostic Values of Circadian Genes CSNK1E/GNA11/KLF9/THRAP3 in Kidney Renal Clear Cell Carcinoma via a Comprehensive Analysis
by Shujing Li, Xianggang Wang, Qingqing Wang, Kaixin Ding, Xin Chen, Yun Zhao, Yu Gao and Yuanyuan Wang
Bioengineering 2022, 9(7), 306; https://doi.org/10.3390/bioengineering9070306 - 11 Jul 2022
Cited by 9 | Viewed by 1933
Abstract
Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent and deadly types of renal cancer in adults. Recent research has identified circadian genes as being involved in the development and progression of KIRC by altering their expression. This study aimed [...] Read more.
Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent and deadly types of renal cancer in adults. Recent research has identified circadian genes as being involved in the development and progression of KIRC by altering their expression. This study aimed to identify circadian genes that are differentially expressed in KIRC and assess their role in KIRC progression. In KIRC, there were 553 differentially expressed rhythm genes (DERGs), with 300 up-regulated and 253 down-regulated DERGs. Functional enrichment analyses showed that DERGs were greatly enriched in the circadian rhythm and immune response pathways. Survival analyses indicated that higher expression levels of CSNK1E were related to shorter overall survival of KIRC patients, whereas lower expression levels of GNA11, KLF9, and THRAP3 were associated with shorter overall survival of KIRC patients. Through cell assay verification, the mRNA level of CSNK1E was significantly up-regulated, whereas the mRNA levels of GNA11, KLF9, and THRAP3 were dramatically down-regulated in KIRC cells, which were consistent with the bioinformatics analysis of KIRC patient samples. Age, grade, stage, TM classification, and CSNK1E expression were all shown to be high-risk variables, whereas GNA11, KLF9, and THRAP3 expression were found to be low-risk factors in univariate Cox analyses. Multivariate Cox analyses showed that CSNK1E and KLF9 were also independently related to overall survival. Immune infiltration analysis indicated that the proportion of immune cells varied greatly between KIRC tissues and normal tissue, whereas CSNK1E, GNA11, KLF9, and THRAP3 expression levels were substantially linked with the infiltration abundance of immune cells and immunological biomarkers. Moreover, interaction networks between CSNK1E/GNA11/KLF9/THRAP3 and immune genes were constructed to explore the stream connections. The findings could help us better understand the molecular mechanisms of KIRC progression, and CSNK1E/GNA11/KLF9/THRAP3 might be used as molecular targets for chronotherapy in KIRC patients in the near future. Full article
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