Recent Advance in the Application of Bioprint and Biomaterials

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 7344

Special Issue Editors


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Guest Editor
Department of Mechanical and Vehicle Engineering, Hunan University, Changsha, China
Interests: 3D printing; biodegradable polymer; bioprinting; controlled drug release; tissue engineering
Faculty of Engineering, University of Nottingham, Nottingham, UK
Interests: multi-material additive manufacturing; biomaterials; photoreactive formulations; inkjet based 3D printing

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Guest Editor
School of Life Sciences, Hunan University, Changsha, China
Interests: polymer biomaterials; hydrogel; tissue regeneration

Special Issue Information

Dear Colleagues,

Artificial tissues and organs with similar functions and architecture to their biological counterpart are used for reducing medical testing costs, addressing problems in tissue placement and organ shortage in transplantation. Three-dimensional bioprinting, a state of the art technology, allows biomaterials, cells and growth factors to be integrated and patterned on demand. It is gaining overwhelming interest from clinicians and researchers due to its ability to fabricate highly sophisticated constructs. Three-dimensional bioprinting technologies are an extensible application of additive manufacturing technologies, including extrusion-based, projection-based, inkjet-based and laser-based printing techniques. The bioink, a combination of structure material, cells, growth factors and other components, is structured in a layer-by-layer manner into desired geometries or devices. The recent application of bioprinting includes scaffolds or scaffolds-free constructs, organs, tissues, organ-on-a-chip, etc. This Special Issue seeks articles that present novel bioinks, new manufacturing technologies, new bioprinting protocols and designs in the bioprinting field that will lead to physiologically optimized artificial constructs with particular interests in:

  1. New bioprinting technologies;
  2. Novel functional, biocompatible material/bioink formulations for bioprinting;
  3. Bioprinting mathematical modelling and design optimization;
  4. Bioprinted devices with controlled releasing of active ingredients (drug, growth factors, etc.);
  5. Multi-material/multi-functional devices for tissue engineering/drug screening;
  6. Design and application of medical-related new materials;
  7. Evaluation and analysis of biocompatibility and safety of medical implants by bioprinting;
  8. 4D bioprinting;
  9. Recent progress in other bioprinting-related fields.

Prof. Dr. Xiaoxiao Han
Dr. Yinfeng He
Dr. Liyang Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • biomaterials
  • tissue engineering
  • controlled release
  • 4D printing

Published Papers (3 papers)

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Research

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13 pages, 3496 KiB  
Article
Customised 3D-Printed Surgical Guide for Breast-Conserving Surgery after Neoadjuvant Chemotherapy and Its Clinical Application
by Jie Luo, Feng Chen, Hong Cao, Wei Zhu, Jian Deng, Dan Li, Wei Li, Junjie Deng, Yangyan Zhong, Haigang Feng, Yilin Li, Xiongmeiyu Gong, Jutao Zeng and Jiaren Chen
Bioengineering 2023, 10(11), 1296; https://doi.org/10.3390/bioengineering10111296 - 09 Nov 2023
Viewed by 1106
Abstract
For patients eligible to undergo breast-conserving surgery (BCS) after neoadjuvant chemotherapy, accurate preoperative localisation of tumours is vital to ensure adequate tumour resection that can reduce recurrence probability effectively. For this reason, we have developed a 3D-printed personalised breast surgery guide (BSG) assisted [...] Read more.
For patients eligible to undergo breast-conserving surgery (BCS) after neoadjuvant chemotherapy, accurate preoperative localisation of tumours is vital to ensure adequate tumour resection that can reduce recurrence probability effectively. For this reason, we have developed a 3D-printed personalised breast surgery guide (BSG) assisted with supine magnetic resonance imaging (MRI) and image 3D reconstruction technology, capable of mapping the tumour area identified on MRI onto the breast directly using dual positioning based on the manubrium and nipple. In addition, the BSG allows the colour dye to be injected into the breast to mark the tumour region to be removed, yielding more accurate intraoperative resection and satisfactory cosmetic outcomes. The device has been applied to 14 patients from January 2018 to July 2023, with two positive margins revealed by the intraoperative biopsy. This study showed that the BSG-based method could facilitate precise tumour resection of BCS by accurately localising tumour extent and margin, promoting the clinical efficacy in patients with breast cancer as well as simplifying the surgical process. Full article
(This article belongs to the Special Issue Recent Advance in the Application of Bioprint and Biomaterials)
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Review

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15 pages, 1631 KiB  
Review
3D Printing and Its Current Status of Application in Obstetrics and Gynecological Diseases
by Caihong Hu, Weishe Zhang and Ping Li
Bioengineering 2023, 10(3), 299; https://doi.org/10.3390/bioengineering10030299 - 27 Feb 2023
Cited by 6 | Viewed by 1914
Abstract
3D printing technology is a novel method of utilizing computer-generated three-dimensional models for drawing, assembling special bioinks, and manufacturing artificial organs and biomedical products. In recent years, it has evolved into a relatively mature therapeutic approach and has been widely used in clinical [...] Read more.
3D printing technology is a novel method of utilizing computer-generated three-dimensional models for drawing, assembling special bioinks, and manufacturing artificial organs and biomedical products. In recent years, it has evolved into a relatively mature therapeutic approach and has been widely used in clinical and basic research. In the field of obstetrics and gynecology, 3D printing technology has been applied for various purposes, including disease diagnosis, treatment, pathogenesis research, and medical education. Notably, researchers have gained significant application experience in common gynecological and obstetrical disorders, such as intrauterine adhesions, uterine tumors, congenital malformations, and fetal congenital abnormalities. This review aims to provide a systematical summary of current research on the application of 3D bioprinting technology in the field of obstetrics and gynecology. Full article
(This article belongs to the Special Issue Recent Advance in the Application of Bioprint and Biomaterials)
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20 pages, 1701 KiB  
Review
The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives
by Ping Li, Jiajia Hu, Jian Wang, Junjie Zhang, Lu Wang and Chengliang Zhang
Bioengineering 2023, 10(2), 165; https://doi.org/10.3390/bioengineering10020165 - 27 Jan 2023
Cited by 9 | Viewed by 3182
Abstract
A myocardial infarction (MI) is the leading cause of morbidity and mortality, seriously threatens human health, and becomes a major health burden of our society. It is urgent to pursue effective therapeutic strategies for the regeneration and restore myocardial function after MI. This [...] Read more.
A myocardial infarction (MI) is the leading cause of morbidity and mortality, seriously threatens human health, and becomes a major health burden of our society. It is urgent to pursue effective therapeutic strategies for the regeneration and restore myocardial function after MI. This review discusses the role of hydrogel in cardiac repair and regeneration for MI. Hydrogel-based cardiac patches and injectable hydrogels are the most commonly used applications in cardiac regeneration medicine. With injectable hydrogels, bioactive compounds and cells can be delivered in situ, promoting in situ repair and regeneration, while hydrogel-based cardiac patches reduce myocardial wall stress, which passively inhibits ventricular expansion. Hydrogel-based cardiac patches work as mechanically supportive biomaterials. In cardiac regeneration medicine, clinical trials and commercial products are limited. Biomaterials, biochemistry, and biological actives, such as intelligent hydrogels and hydrogel-based exosome patches, which may serve as an effective treatment for MI in the future, are still under development. Further investigation of clinical feasibility is warranted. We can anticipate hydrogels having immense translational potential for cardiac regeneration in the near future. Full article
(This article belongs to the Special Issue Recent Advance in the Application of Bioprint and Biomaterials)
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