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Bioengineering
Special Issues
Wound Healing and Regenerative Medicine
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Wound Healing and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 6371

Special Issue Editors

Prof. Dr. Geoffrey C. Gurtner

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Guest Editor
Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724, USA
Interests: diabetes; bioengineering; tissue engineering; microfluidics; wound healing
Prof. Dr. Kellen Chen

E-Mail Website
Guest Editor
Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724, USA
Interests: wound healing; cell and tissue biomechanics; fibrosis; regeneration; mechanotransduction

Special Issue Information

Dear Colleagues,

After injury, the body undergoes a complicated healing process that could lead to either fibrotic tissue repair or tissue regeneration. In humans, these injuries result in scar tissue formation and diminished function of the organ of interest.

Over the past few decades, significant advances in bioengineering technologies have drastically improved our ability to fine tune molecular, cellular, and tissue healing kinetics across a vast range of organ systems and disease states. These developments have opened up a new frontier in novel biomedical engineering techniques for the promotion of healing and regeneration.

In this Special Issue, we aim to capture the application of a diverse range of new biomedical technologies in fields such as biomolecular/cellular/tissue engineering, biomaterials, biomimetics, biomechanics, bioelectronics, and biochemical engineering to study new translational avenues for wound healing and regenerative medicine. This Special Issue will demonstrate how these techniques can modulate cellular recruitment, cellular signaling, molecular machinery, extracellular matrix deposition, and subsequent tissue remodeling to promote beneficial healing or even regeneration after injury.

Prof. Dr. Geoffrey C. Gurtner
Prof. Dr. Kellen Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

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17 pages, 6194 KiB  
Review
Advances in Zebrafish for Diabetes Mellitus with Wound Model
by Bangchang Lin, Jiahui Ma, Yimeng Fang, Pengyu Lei, Lei Wang, Linkai Qu, Wei Wu, Libo Jin and Da Sun
Bioengineering 2023, 10(3), 330; https://doi.org/10.3390/bioengineering10030330 - 06 Mar 2023
Cited by 7 | Viewed by 2860
Abstract
Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal wound healing involves hemostasis, inflammation, proliferation, and remodeling. However, the negative factors associated with diabetes, such as bacterial biofilms, persistent inflammation, impaired angiogenesis, inhibited cell proliferation, and pathological scarring, [...] Read more.
Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal wound healing involves hemostasis, inflammation, proliferation, and remodeling. However, the negative factors associated with diabetes, such as bacterial biofilms, persistent inflammation, impaired angiogenesis, inhibited cell proliferation, and pathological scarring, greatly interfere with the smooth progress of the entire healing process. It is this impaired wound healing that leads to diabetic foot ulcers and even amputations. Therefore, drug screening is challenging due to the complexity of damaged healing mechanisms. The establishment of a scientific and reasonable animal experimental model contributes significantly to the in-depth research of diabetic wound pathology, prevention, diagnosis, and treatment. In addition to the low cost and transparency of the embryo (for imaging transgene applications), zebrafish have a discrete wound healing process for the separate study of each stage, resulting in their potential as the ideal model animal for diabetic wound healing in the future. In this review, we examine the reasons behind the delayed healing of diabetic wounds, systematically review various studies using zebrafish as a diabetic wound model by different induction methods, as well as summarize the challenges and improvement strategies which provide references for establishing a more reasonable diabetic wound zebrafish model. Full article
(This article belongs to the Special Issue Wound Healing and Regenerative Medicine)
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Other

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23 pages, 2431 KiB  
Systematic Review
Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis
by Eduardo Anitua, Mikel Allende, María de la Fuente, Massimo Del Fabbro and Mohammad Hamdan Alkhraisat
Bioengineering 2023, 10(3), 303; https://doi.org/10.3390/bioengineering10030303 - 27 Feb 2023
Cited by 7 | Viewed by 3027
Abstract
Assisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich [...] Read more.
Assisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich plasma (PRP) therapies use a patient’s own platelets to promote tissue healing and growth, including endometrium. The growth factors provided by the platelets play a criterial role on the regenerative ability of PRP. In the last years, PRP treatments have been gaining a lot of popularity to treat women with repeated ART failures. In this study, we collected and summarized all information published in the scientific literature to assess the evidence of the PRP effect on pregnancy. We only considered randomized controlled trials (RCT), a type of study designed to be unbiased and considered at the highest level of evidence. Our analysis indicates that PRP therapies might be an effective treatment in cases of poor responsiveness to conventional ART. However, additional studies (well-designed) are necessary to confirm this beneficial effect of PRP. Full article
(This article belongs to the Special Issue Wound Healing and Regenerative Medicine)
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