Recent Advances in Polymeric Biomaterials for Wound Healing Applications

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2348

Special Issue Editor


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Guest Editor
1. Department of Biological Sciences, Wichita State University, Wichita, KS 67260, USA
2. Department of Orthopaedic Surgery, University of Kansas School of Medicine-Wichita, Wichita, KS 67214, USA
Interests: polymeric biomaterials; wound healing; bone graft; biocompatibility

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Polymeric Biomaterials for Wound Healing Applications," provides an in-depth exploration of the advancements, innovations, and applications of polymeric biomaterials in wound healing. Its objective is to discuss the development and utilization of various polymeric materials as scaffolds, dressings, or coatings to promote and enhance the wound healing process.

First, the properties of polymeric biomaterials that make them suitable for wound healing applications are discussed, including biocompatibility, biodegradability, and their ability to provide mechanical support to the wound site. In addition, various types of polymeric scaffolds, dressings, and coatings that facilitate tissue regeneration and promote wound closure are explored.

The recent advancements in the design and fabrication of polymeric biomaterials with controlled release capabilities are highlighted, which allow for the sustained delivery of bioactive molecules such as growth factors, antibiotics, and anti-inflammatory agents to enhance wound healing efficiency.

Furthermore, this Special Issue examines the utilization of tissue engineering approaches combined with polymeric biomaterials to create three-dimensional structures that mimic the native extracellular matrix, supporting cell attachment, proliferation, and differentiation.

The challenges and future perspectives in the field of polymeric biomaterials for wound healing are also explored, including strategies to overcome limitations such as immune response, infection control, and wound chronicity.

Prof. Dr. Shangyou Yang
Guest Editor

Manuscript Submission Information

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Keywords

  • polymeric biomaterials
  • wound healing
  • scaffolds
  • dressings
  • coatings
  • tissue regeneration
  • tissue engineering
  • biocompatibility
  • biodegradability
  • controlled release

Published Papers (1 paper)

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23 pages, 8275 KiB  
Article
Fabrication, Characterization, and In Vitro Cytotoxicity Assessment of Tri-Layered Multifunctional Scaffold for Effective Chronic Wound Healing
by Ahmed Olanrewaju Ijaola, Balakrishnan Subeshan, Anh Pham, Md. Nizam Uddin, Shang-You Yang and Eylem Asmatulu
Bioengineering 2023, 10(10), 1148; https://doi.org/10.3390/bioengineering10101148 - 30 Sep 2023
Cited by 1 | Viewed by 1169
Abstract
Chronic wounds have been a global health risk that demands intensive exploration. A tri-layered biomaterial scaffold has been developed for skin wounds. The top layer of the scaffold is superhydrophobic, and the bottom layer is hydrophilic, both of which were electrospun using recycled [...] Read more.
Chronic wounds have been a global health risk that demands intensive exploration. A tri-layered biomaterial scaffold has been developed for skin wounds. The top layer of the scaffold is superhydrophobic, and the bottom layer is hydrophilic, both of which were electrospun using recycled expanded polystyrene (EPS) and monofilament fishing line (MFL), respectively. The intermediate layer of the scaffold comprised hydrogel by cross-linking chitosan (CS) with polyethylene glycol. The surface morphology, surface chemistry, thermal degradation, and wettability characteristics of each layer of the scaffold were examined. Also, the antibacterial activity and in vitro cytotoxicity study on the combined tri-layered scaffold were assessed against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Data revealed exceptional water repellency of the heat-treated electrospun top superhydrophobic layer (TSL) with a high-water contact angle (WCA) of 172.44°. A TSL with 15 wt% of micro-/nano-inclusions had the best thermal stability above 400 °C. The bottom hydrophilic layer (BHL) displayed a WCA of 9.91°. Therapeutically, the synergistic effect of the combined tri-layered scaffold significantly inhibited bacteria growth by 70.5% for E. coli and 68.6% for S. aureus. Furthermore, cell viability is enhanced when PEG is included as part of the intermediate CS hydrogel layer (ICHL) composition. Full article
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