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Bioengineering
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Bone Tissue Engineering and Translational Research
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Bone Tissue Engineering and Translational Research

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 6796

Special Issue Editors

Dr. Xinggui Tian

E-Mail Website
Guest Editor
1. University Center of Orthopaedic, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at Technische Universität Dresden, 01307 Dresden, Germany
2. Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus at Technische Universität Dresden, 01307 Dresden, Germany
Interests: biomaterials; bone tissue engineering; bone regeneration; drug delivery; 3D printing; spinal fusion
Dr. Yang Liu

E-Mail Website
Guest Editor
1. Department of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden
2. Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310030, China
Interests: bone tissue engineering; biomaterials; drug delivery; target delivery; bone regeneration; bone cancer
Dr. Ming Luo

E-Mail Website
Guest Editor
Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Interests: bone cancer; bone tissue engineering; skeletal muscle regeneration

Special Issue Information

Dear Colleagues,

With the development of bioengineering, especially in materials science, bone tissue engineering is playing an increasingly important role in the treatment of bone and joint diseases. At present, clinical problems such as critical-size bone and cartilage defects, malignant bone tumors, deep bone infection and pseudarthrosis of the spine, still challenge orthopedic surgeons, and require further joint efforts from researchers, engineers, and clinicians. Advances in bone tissue engineering technology have brought new opportunities for the treatment of bone and joint diseases, including facile 3D printing or bioprinting, newly fabricated bionic biomaterials and novel drug delivery systems with more accurate targeting. However, much of the research is still at the initial stage, on the bench side, and need to be further explored in preclinical settings or even clinical scenarios. Thus, translational research is necessary to truly improve human health, which would allow for advances in basic research from the laboratory also be applicable under clinical scenario. This Special Issue will focus on bone tissue engineering and its translational research for bone and joint diseases, aiming to narrow the gap between the basic tissue engineering research and its medical application. Potential topics include but are not limited to the following: 3D printing, bioprinting, drug delivery, bioactive material, bone and cartilage defect repair, bone tumor, bone infection, and spinal fusion.

We would be delighted if you could submit your manuscripts (full articles, review papers) to this Special Issue.

Dr. Xinggui Tian
Dr. Yang Liu
Dr. Ming Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • biomaterials
  • drug delivery
  • bone tissue engineering
  • bone regeneration
  • cartilage regeneration
  • bone cancer
  • bone infection
  • spinal fusion

Published Papers (4 papers)

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Research

18 pages, 5025 KiB  
Article
Three-Dimensional Printing of Drug-Eluting Implantable PLGA Scaffolds for Bone Regeneration
by Manjusha Annaji, Nur Mita, Ishwor Poudel, Sai H. S. Boddu, Oladiran Fasina and R. Jayachandra Babu
Bioengineering 2024, 11(3), 259; https://doi.org/10.3390/bioengineering11030259 - 06 Mar 2024
Viewed by 896
Abstract
Despite rapid progress in tissue engineering, the repair and regeneration of bone defects remains challenging, especially for non-homogenous and complicated defects. We have developed and characterized biodegradable drug-eluting scaffolds for bone regeneration utilizing direct powder extrusion-based three-dimensional (3D) printing techniques. The PLGA scaffolds [...] Read more.
Despite rapid progress in tissue engineering, the repair and regeneration of bone defects remains challenging, especially for non-homogenous and complicated defects. We have developed and characterized biodegradable drug-eluting scaffolds for bone regeneration utilizing direct powder extrusion-based three-dimensional (3D) printing techniques. The PLGA scaffolds were fabricated using poly (lactic-co-glycolic acid) (PLGA) with inherent viscosities of 0.2 dl/g and 0.4 dl/g and ketoprofen. The effect of parameters such as the infill, geometry, and wall thickness of the drug carrier on the release kinetics of ketoprofen was studied. The release studies revealed that infill density significantly impacts the release performance, where 10% infill showed faster and almost complete release of the drug, whereas 50% infill demonstrated a sustained release. The Korsmeyer–Peppas model showed the best fit for release data irrespective of the PLGA molecular weight and infill density. It was demonstrated that printing parameters such as infill density, scaffold wall thickness, and geometry played an important role in controlling the release and, therefore, in designing customized drug-eluting scaffolds for bone regeneration. Full article
(This article belongs to the Special Issue Bone Tissue Engineering and Translational Research)
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21 pages, 9917 KiB  
Article
3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering
by Giovanna Strangis, Massimiliano Labardi, Giuseppe Gallone, Mario Milazzo, Simone Capaccioli, Francesca Forli, Patrizia Cinelli, Stefano Berrettini, Maurizia Seggiani, Serena Danti and Paolo Parchi
Bioengineering 2024, 11(2), 193; https://doi.org/10.3390/bioengineering11020193 - 17 Feb 2024
Viewed by 1363
Abstract
Bone defects are a significant health problem worldwide. Novel treatment approaches in the tissue engineering field rely on the use of biomaterial scaffolds to stimulate and guide the regeneration of damaged tissue that cannot repair or regrow spontaneously. This work aimed at developing [...] Read more.
Bone defects are a significant health problem worldwide. Novel treatment approaches in the tissue engineering field rely on the use of biomaterial scaffolds to stimulate and guide the regeneration of damaged tissue that cannot repair or regrow spontaneously. This work aimed at developing and characterizing new piezoelectric scaffolds to provide electric bio-signals naturally present in bone and vascular tissues. Mixing and extrusion were used to obtain nanocomposites made of polyhydroxybutyrate (PHB) as a matrix and barium titanate (BaTiO3) nanoparticles as a filler, at BaTiO3/PHB compositions of 5/95, 10/90, 15/85 and 20/80 (w/w%). The morphological, thermal, mechanical and piezoelectric properties of the nanocomposites were studied. Scanning electron microscopy analysis showed good nanoparticle dispersion within the polymer matrix. Considerable increases in the Young’s modulus, compressive strength and the piezoelectric coefficient d31 were observed with increasing BaTiO3 content, with d31 = 37 pm/V in 20/80 (w/w%) BaTiO3/PHB. 3D printing was used to produce porous cubic-shaped scaffolds using a 90° lay-down pattern, with pore size ranging in 0.60–0.77 mm and good mechanical stability. Biodegradation tests conducted for 8 weeks in saline solution at 37 °C showed low mass loss (∼4%) for 3D printed scaffolds. The results obtained in terms of piezoelectric, mechanical and chemical properties of the nanocomposite provide a new promising strategy for vascularized bone tissue engineering. Full article
(This article belongs to the Special Issue Bone Tissue Engineering and Translational Research)
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19 pages, 10731 KiB  
Article
Improvement of Metal-Doped β-TCP Scaffolds for Active Bone Substitutes via Ultra-Short Laser Structuring
by Íris Soares, Lamborghini Sotelo, Ina Erceg, Florian Jean, Marie Lasgorceix, Anne Leriche, Maja Dutour Sikirić, Katarina Marušić, Silke Christiansen and Albena Daskalova
Bioengineering 2023, 10(12), 1392; https://doi.org/10.3390/bioengineering10121392 - 06 Dec 2023
Viewed by 1049
Abstract
Various efforts have been made to develop antibacterial biomaterials capable of also sustaining bone remodulation to be used as bone substitutes and reduce patient infection rates and related costs. In this work, beta-tricalcium phosphate (β-TCP) was chosen due to its known biocompatibility and [...] Read more.
Various efforts have been made to develop antibacterial biomaterials capable of also sustaining bone remodulation to be used as bone substitutes and reduce patient infection rates and related costs. In this work, beta-tricalcium phosphate (β-TCP) was chosen due to its known biocompatibility and use as a bone substitute. Metal dopants were incorporated into the crystal structure of the β-TCP, and disks were produced from this material. Magnesium and strontium, as well as copper and silver, were chosen as dopants to improve the osteogenic and antibacterial properties, respectively. The surface of the β-TCP samples was further modified using a femtosecond laser system. Grid and line patterns were produced on the plates’ surface via laser ablation, creating grooves with depths lower than 20 μm and widths between 20 and 40 μm. Raman and FTIR analysis confirmed that laser ablation did not result in the degradation or phase change of the materials, making it suitable for surface patterning. Laser ablation resulted in increased hydrophilicity of the materials, as the control samples (non-ablated samples) have WCA values ranging from 70° to 93° and become, upon laser ablation, superwicking surfaces. Confocal measurements show an increase in specific surface area of 50% to 200% compared to the control. Overall, the results indicate the potential of laser ablation to improve the surface characteristics of β-TCP, which may lead to an improvement in the antibacterial and osteogenic properties of the produced materials. Full article
(This article belongs to the Special Issue Bone Tissue Engineering and Translational Research)
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16 pages, 11379 KiB  
Article
Development of Novel Polysaccharide Membranes for Guided Bone Regeneration: In Vitro and In Vivo Evaluations
by Naïma Ahmed Omar, Jéssica Roque, Paul Galvez, Robin Siadous, Olivier Chassande, Sylvain Catros, Joëlle Amédée, Samantha Roques, Marlène Durand, Céline Bergeaut, Laurent Bidault, Paola Aprile, Didier Letourneur, Jean-Christophe Fricain and Mathilde Fenelon
Bioengineering 2023, 10(11), 1257; https://doi.org/10.3390/bioengineering10111257 - 28 Oct 2023
Viewed by 1026
Abstract
Introduction: Guided bone regeneration (GBR) procedures require selecting suitable membranes for oral surgery. Pullulan and/or dextran-based polysaccharide materials have shown encouraging results in bone regeneration as bone substitutes but have not been used to produce barrier membranes. The present study aimed to develop [...] Read more.
Introduction: Guided bone regeneration (GBR) procedures require selecting suitable membranes for oral surgery. Pullulan and/or dextran-based polysaccharide materials have shown encouraging results in bone regeneration as bone substitutes but have not been used to produce barrier membranes. The present study aimed to develop and characterize pullulan/dextran-derived membranes for GBR. Materials and methods: Two pullulan/dextran-based membranes, containing or not hydroxyapatite (HA) particles, were developed. In vitro, cytotoxicity evaluation was performed using human bone marrow mesenchymal stem cells (hBMSCs). Biocompatibility was assessed on rats in a subcutaneous model for up to 16 weeks. In vivo, rat femoral defects were created on 36 rats to compare the two pullulan/dextran-based membranes with a commercial collagen membrane (Bio-Gide®). Bone repair was assessed radiologically and histologically. Results: Both polysaccharide membranes demonstrated cytocompatibility and biocompatibility. Micro-computed tomography (micro-CT) analyses at two weeks revealed that the HA-containing membrane promoted a significant increase in bone formation compared to Bio-Gide®. At one month, similar effects were observed among the three membranes in terms of bone regeneration. Conclusion: The developed pullulan/dextran-based membranes evidenced biocompatibility without interfering with bone regeneration and maturation. The HA-containing membrane, which facilitated early bone regeneration and offered adequate mechanical support, showed promising potential for GBR procedures. Full article
(This article belongs to the Special Issue Bone Tissue Engineering and Translational Research)
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