Reconstruction Technologies of Complex Oncologic Defects

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (1 January 2024) | Viewed by 1203

Special Issue Editors


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Guest Editor
Department of Surgery, McGill University, Montreal, QC, Canada
Interests: foreign body reactions; peri-prosthetic disease; tissue-implant interactions; breast cancer reconstruction

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Guest Editor
Orthopedic Surgery, McGill University, Montreal, QC, Canada
Interests: osteoimmunology; bone repair; inorganic polyphosphates; hypoxia; tissue engineering; ligaments; tendons; bone healing; drug release

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Guest Editor
Division of Orthopaedic Surgery, Department of Surgery, McGill University, Montreal, QC H3A 0G4, Canada
Interests: 3D printing; biofabrication; drug delivery; musculoskeletal disease; bone/ligament repair; bone metastases; scaffolds
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Special Issue Information

Dear Colleagues,

The capacity to reconstruct the bony and soft tissue defects resulting from oncologic resection remains a critical limiting factor in whether a tumor is deemed resectable. Advances in biomaterial innovation and bioengineering have yielded a breadth of novel treatment strategies for reconstructing oncologic defects, expanding the indications for tumor extirpation. The specific requirements of individual defects—structural, functional, and aesthetic, spanning a wide range of anatomic areas—are all important considerations and broad innovation is required in order to advance reconstructive modalities. Current standard repair strategies all have unwanted drawbacks, necessitating the need to improve repair strategies.

In this Special Issue, we will celebrate novel and cutting-edge strategies developed for use in improved oncologic defect repair. An example of such a method would be the use of biomaterial innovations to recreate rigid structural tissues in the case of bony defects or deformable materials in order to reconstruct soft tissue defects, cell-based therapies, and printed scaffolds which restore tissue integrity with viable materials, and the deploymenty of many more different emerging techniques to reconstruct complex oncologic defects. We welcome full-length original research studies, letters, clinical cases, and reviews outlining advances in oncologic reconstruction technology.

Dr. Joshua Vorstenbosch
Dr. Rahul Gawri
Dr. Derek H. H. Rosenzweig
Guest Editors

Manuscript Submission Information

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Keywords

  • oncologic reconstruction
  • biomaterials
  • tissue scaffolds
  • cell-based therapies
  • tissue engineering
  • surgical oncology
  • medical devices
  • 3D printing
  • drug delivery

Published Papers (1 paper)

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Research

11 pages, 2132 KiB  
Article
Biological Prosthesis (Hollow 3D-Printed Titanium Custom-Made Prosthesis and Bone Graft) for Humeral Reconstruction in Pediatric Oncologic Patients: Surgical Indications and Results
by Giovanni Beltrami, Sreeraj Rajan, Anna Maria Nucci, Alberto Galeotti, Davide Guido, Domenico Campanacci and Marco Innocenti
Bioengineering 2023, 10(12), 1371; https://doi.org/10.3390/bioengineering10121371 - 29 Nov 2023
Viewed by 998
Abstract
This study presents the mid-term outcomes of a novel “biological prosthesis” for pediatric humerus reconstruction after major bone tumor removal. This approach involves a hollow 3D-printed titanium custom-made prosthesis combined with bone grafting. The primary aim was to preserve and revitalize the unaffected [...] Read more.
This study presents the mid-term outcomes of a novel “biological prosthesis” for pediatric humerus reconstruction after major bone tumor removal. This approach involves a hollow 3D-printed titanium custom-made prosthesis combined with bone grafting. The primary aim was to preserve and revitalize the unaffected autologous proximal or distal humeral stump. Between 2017 and 2021, we treated five pediatric patients (mean age 11.2 years; range 7–17) with humeral bone sarcomas. A one-stage surgical procedure involved tumor resection and implanting a hollow 3D-printed custom-made prosthesis. In two cases, we preserved the proximal humerus; in two, the distal part; and in one, both. Graft materials included homologous bone chips in three cases and free vascularized fibular grafts in two cases. All patients were clinically and radiographically assessed after a mean follow-up of 32.2 months (range of 14–68). No significant complications were observed, and no implant revisions were needed. Osseointegration was evident in all cases within eight months post-surgery; vascular support for the remaining autologous stump was demonstrated in all cases. Our hollow 3D-printed custom-made prosthesis and bone grafting offer the potential for partial or complete articular surface preservation. This approach encourages revascularization of the epiphysis, leading to satisfactory outcomes in humerus reconstruction within the pediatric population. Full article
(This article belongs to the Special Issue Reconstruction Technologies of Complex Oncologic Defects)
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