Special Issue "Recent Advances and Novel Strategies against Inflammatory Diseases: Targeted Drug Discovery and Delivery"

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".

Deadline for manuscript submissions: 24 December 2023 | Viewed by 930

Special Issue Editors

College of Pharmacy, Southwest Minzu University, Chengdu, China
Interests: inflammation therapy; drug delivery; nanomaterials; macromolecular carriers
West China School/Hospital of Stomatology, Sichuan University, Chengdu, China
Interests: antibacterial therapy; biomaterials; cancer therapy; drug delivery and nanomaterials
NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia
Interests: biomaterials; nanoparticles; drug delivery; cancer therapy; neurological disorder treatment
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Special Issue Information

Dear Colleagues,

Inflammation is known to be a protective immune response for maintaining tissue homeostasis by eliminating harmful stimuli, including damaged cells, irritants, pathogens, and sterile lesions. Cell interactions in the innate immune system, adaptive immune system, and inflammatory mediators are involved in various types of inflammatory diseases, including acute disorders such as acute liver injury and acute lung injury, as well as chronic disorders such as autoimmune and cancer. These inflammatory diseases pose a crucial threat to human life and health; therefore, it is urgent that specific, quick, and effective prevention, diagnosis, and cures are explored for these inflammatory diseases.

This research topic welcomes submissions of original research articles and reviews that are related to novel drugs and drug delivery systems, including newly active compounds, nano drugs, vaccines, biosensors, nano-delivery systems, micro-delivery systems, macromolecular carrier drug conjugates, prodrugs, and biological therapies for the diagnosis, prevention, and treatment of inflammatory diseases. Potential subtopics include, but are not limited to, the following areas:

  1. Newly discovered pathogenesis and targets of inflammatory diseases;
  2. Nanomaterial-assisted or biomaterial-assisted drug delivery strategies;
  3. Therapeutic nanomaterials for inflammatory diseases;
  4. Novel nanotherapeutic strategies;
  5. Diagnostic uses of nanomaterials or biomaterials;
  6. Vaccines and biosensors for inflammatory diseases;
  7. Newly active compounds, micro/nanocrystal drugs, macromolecular carrier drug conjugates, and prodrugs against inflammatory diseases;
  8. Pharmacokinetics of drugs and prodrugs for inflammatory diseases;
  9. Discussing the latest progress in inflammatory diseases;
  10. Exploring the potential of biological therapies for inflammatory diseases;
  11. Discover or construct new drug carriers to treat inflammatory diseases.

Prof. Dr. Zhi-Xiang Yuan
Dr. Qiang Peng
Dr. Tianqing (Michelle) Liu
Guest Editors

Manuscript Submission Information

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  • inflammation
  • immunity
  • anti-inflammatory drugs
  • delivery systems
  • nanomaterials

Published Papers (1 paper)

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Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane
Bioengineering 2023, 10(6), 740; https://doi.org/10.3390/bioengineering10060740 - 20 Jun 2023
Cited by 1 | Viewed by 573
The aim of this study was to compare concentrations of endogenous N-acylethanolamine (NAE) lipid mediators—palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA)—in fresh, decontaminated, cryopreserved, and freeze-dried amniotic membrane (AM) allografts, thereby determining whether AM’s analgesic and anti-inflammatory efficiency related to NAEs persists during [...] Read more.
The aim of this study was to compare concentrations of endogenous N-acylethanolamine (NAE) lipid mediators—palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and anandamide (AEA)—in fresh, decontaminated, cryopreserved, and freeze-dried amniotic membrane (AM) allografts, thereby determining whether AM’s analgesic and anti-inflammatory efficiency related to NAEs persists during storage. The concentrations of NAEs were measured using ultra-high-performance liquid chromatography–tandem mass spectrometry. Indirect fluorescent immunohistochemistry was used to detect the PEA PPAR-α receptor. The concentrations of PEA, OEA, and AEA were significantly higher after decontamination. A significant decrease was found in cryopreserved AM compared to decontaminated tissue for PEA but not for OEA and AEA. However, significantly higher values for all NAEs were detected in cryopreserved samples compared to fresh tissue before decontamination. The freeze-dried AM had similar values to decontaminated AM with no statistically significant difference. The nuclear staining of the PPAR-α receptor was clearly visible in all specimens. The stability of NAEs in AM after cryopreservation was demonstrated under tissue bank storage conditions. However, a significant decrease, but still higher concentration of PEA compared to fresh not decontaminated tissue, was found in cryopreserved, but not freeze-dried, AM. Results indicate that NAEs persist during storage in levels sufficient for the analgesic and anti-inflammatory effects. This means that cryopreserved AM allografts released for transplant purposes before the expected expiration (usually 3–5 years) will still show a strong analgesic effect. The same situation was confirmed for AM lyophilized after one year of storage. This work thus contributed to the clarification of the analgesic effect of NAEs in AM allografts. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Potential of nanomaterials-based photodynamic therapy in antibacterial treatment
Authors: Yujie Gao (the 1st author), Jv Li, Yejiao Luo, Hua Lin, Qiang Peng, Renguo Gong (the corresponding author)
Affiliation: West China School/Hospital of Stomatology, Sichuan University, Chengdu, China
Abstract: Microbial infections have been a persistent health problem for humans, especially with the emergence of drug-resistant bacteria. The failure of traditional antibiotic therapies has led researchers to explore alternative strategies. Photodynamic therapy (PDT) is a promising alternative that generates reactive oxygen species (ROS) to induce bacterial oxidative stress and has the potential for cyclic treatment without causing the development of new drug resistance mechanisms. The efficacy of PDT largely depends on the choice of photosensitizers. At present, various nanomaterials are constructed to be used as drug carriers or photosensitizers to improve the efficacy of PDT in antibacterial field. In this article, we provide a comprehensive review of four main ROS generated in the process of PDT, and summarize their corresponding antibacterial mechanisms. Furthermore, we highlight typical types of nanomaterials used as photosensitizers or carriers in PDT. We analyze the current challenges in the development of nanomaterial-based PDT for antibacterial therapy, and discuss potential strategies for optimizing their applications

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