Proliferation, Differentiation and Metabolism of Stem Cells in Microgravity Environment

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1401

Special Issue Editor


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Guest Editor
Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Interests: conception of space life; early embryonic development; the proliferation, differentiation and metabolism of stem cells in space microgravity environment

Special Issue Information

Dear Colleagues,

Stem cells have shown great potential in regenerative medicine and tissue engineering, but their behavior in microgravity environments remains largely unknown. Investigating the impact of microgravity on stem cells could not only contribute to the advancement of basic science but also provide insights into developing novel cell-based therapies for space exploration and terrestrial applications. The interdisciplinary nature of this research also makes it appropriate for contributions from various fields, including space biology, stem cell biology, tissue engineering, and biomedical engineering.

This Special Issue aims to explore the effects of microgravity on the proliferation, differentiation, and metabolism of stem cells and will cover a wide range of topics related to the effects of microgravity on stem cells. Both original research contributions and review papers are welcome, which may include but are not limited to the following topics.

  1. Changes in stem cell proliferation and differentiation under microgravity conditions (space environment or simulated microgravity).
  2. Alterations in gene expression, epigenetic regulation, and signaling pathways in stem cells in microgravity.
  3. Metabolic adaptations of cell or stem cells in microgravity.
  4. Innovative approaches for culturing and studying stem cells in microgravity, such as biomaterials applied to the long-term growth and differentiation of stem cells under microgravity conditions.
  5. Biomanufacturing in microgravity for regenerative medicine.
  6. Organoid development and tissue engineering research in microgravity.
  7. Ethical considerations and regulatory policies for using stem cells in space exploration.

Dr. Xiaohua Lei
Guest Editor

Manuscript Submission Information

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Keywords

  • microgravity
  • stem cells
  • regenerative medicine
  • 3D in vitro model
  • proliferation
  • differentiation
  • metabolism

Published Papers (1 paper)

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Research

15 pages, 3814 KiB  
Article
Metabolomic Profiling of the Secretome from Human Neural Stem Cells Flown into Space
by Juan Carlos Biancotti and Araceli Espinosa-Jeffrey
Bioengineering 2024, 11(1), 11; https://doi.org/10.3390/bioengineering11010011 - 22 Dec 2023
Viewed by 1066
Abstract
The change in gravitational force has a significant effect on biological tissues and the entire organism. As with any alteration in the environment, microgravity (µG) produces modifications in the system inducing adaptation to the new condition. In this study, we analyzed the effect [...] Read more.
The change in gravitational force has a significant effect on biological tissues and the entire organism. As with any alteration in the environment, microgravity (µG) produces modifications in the system inducing adaptation to the new condition. In this study, we analyzed the effect of µG on neural stem cells (NSCs) following a space flight to the International Space Station (ISS). After 3 days in space, analysis of the metabolome in culture medium revealed increased glycolysis with augmented pyruvate and glycerate levels, and activated catabolism of branched-chain amino acids (BCAA) and glutamine. NSCs flown into space (SPC-NSCs) also showed increased synthesis of NADH and formation of polyamine spermidine when compared to ground controls (GC-NSCs). Overall, the space environment appears to increase energy demands in response to the µG setting. Full article
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