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Bioengineering
Special Issues
Recent Advances of Bone Bioengineering
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Recent Advances of Bone Bioengineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 3307

Special Issue Editor

Dr. Beetin Goh

E-Mail Website
Guest Editor
National Dental Centre of Singapore, Singapore City, Singapore
Interests: bone bioengineering; oral and maxillofacial device development; novel techniques in mandibular reconstruction

Special Issue Information

Dear Colleagues,

Bone is the world’s second-most transplanted tissue. Bone grafts are in high demand globally due to the increasing prevalence of bone damage caused by ageing, diseases, and accidents. The current gold standard for bone graft is the use of autogenous bone, requiring additional donor-site surgery with its associated morbidities and expenses. Bone grafts derived from cadavers or animals carry risks of disease transmission and adverse reactions. To overcome these limitations, there has been interest and significant development in the field of bone bioengineering. Despite significant progress in terms of understanding cell differentiation and signaling mechanisms, manipulating pluripotent stem or progenitor cells and engineering state-of-the-art biomaterials, challenges remain that limit the translation of successes in the laboratory to the clinic.

This Special Issue will focus on the recent developments of clinically relevant bone bioengineering (BBE).

The journal will be accepting contributions (both original research articles and reviews) mainly centered on the following topics:

  • Biocompatible materials for BBE.
  • Material surface property modulation for BBE.
  • Bioactive molecule incorporation for BBE.
  • Novel scaffolds, including 3D-printed scaffolds and bioprinting for BBE.
  • Bioreactors for BBE.
  • Mechanotransduction for BBE.
  • Stem cells for BBE.
  • Animal models for BBE.
  • Clinical trials in BBE.

Dr. Beetin Goh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • materials
  • bioactive molecule
  • scaffolds
  • bioreactors
  • mechanotransduction
  • stem cells

Published Papers (2 papers)

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Research

13 pages, 2980 KiB  
Article
Frozen Stored Teeth: Autogenous Dentin as an Alternative Augmentation Material in Dentistry
by Michael Korsch, Kurt Werner Alt and Frederick Reza Mock
Bioengineering 2023, 10(4), 456; https://doi.org/10.3390/bioengineering10040456 - 07 Apr 2023
Viewed by 1173
Abstract
Tooth Shell Technique (TST) with the use of autologous dentin has proven to be a suitable method of grafting in the context of lateral ridge augmentation. This present feasibility study aimed to retrospectively evaluate the preservation by lyophilization of processed dentin. Thus, the [...] Read more.
Tooth Shell Technique (TST) with the use of autologous dentin has proven to be a suitable method of grafting in the context of lateral ridge augmentation. This present feasibility study aimed to retrospectively evaluate the preservation by lyophilization of processed dentin. Thus, the frozen stored processed dentin matrix (FST: 19 patients with 26 implants) was re-examined with that of processed teeth used immediately after extraction (IUT: 23 patients with 32 implants). Parameters of biological complications, horizontal hard tissue loss, osseointegration, and buccal lamella integrity were used for evaluation. For complications, the observation period was 5 months. Only one graft was lost (IUT group). In the area of minor complications, without the loss of an implant or augmentation, there were two cases of wound dehiscence and one case with inflammation and suppuration (IUT: n = 3, FST: n = 0). Osseointegration and integrity of the buccal lamella were present in all implants without exception. Statistically, there was no difference between the groups studied for the mean resorption of the crestal width and the buccal lamella. Results of this study show that prepared autologous dentin preserved with a conventional freezer had no disadvantage compared to immediately use autologous dentin in terms of complications and graft resorption in the context of TST. Full article
(This article belongs to the Special Issue Recent Advances of Bone Bioengineering)
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19 pages, 9621 KiB  
Article
Adjustment of Micro- and Macroporosity of ß-TCP Scaffolds Using Solid-Stabilized Foams as Bone Replacement
by Lukas Dufner, Bettina Oßwald, Jan Eberspaecher, Bianca Riedel, Chiara Kling, Frank Kern and Michael Seidenstuecker
Bioengineering 2023, 10(2), 256; https://doi.org/10.3390/bioengineering10020256 - 15 Feb 2023
Cited by 2 | Viewed by 1535
Abstract
To enable rapid osteointegration in bioceramic implants and to give them osteoinductive properties, scaffolds with defined micro- and macroporosity are required. Pores or pore networks promote the integration of cells into the implant, facilitating the supply of nutrients and the removal of metabolic [...] Read more.
To enable rapid osteointegration in bioceramic implants and to give them osteoinductive properties, scaffolds with defined micro- and macroporosity are required. Pores or pore networks promote the integration of cells into the implant, facilitating the supply of nutrients and the removal of metabolic products. In this paper, scaffolds are created from ß-tricalciumphosphate (ß-TCP) and in a novel way, where both the micro- and macroporosity are adjusted simultaneously by the addition of pore-forming polymer particles. The particles used are 10–40 wt%, spherical polymer particles of polymethylmethacrylate (PMMA) (Ø = 5 µm) and alternatively polymethylsilsesquioxane (PMSQ) (Ø = 2 µm), added in the course of ß-TCP slurry preparation. The arrangement of hydrophobic polymer particles at the interface of air bubbles was incorporated during slurry preparation and foaming of the slurry. The foam structures remain after sintering and lead to the formation of macro-porosity in the scaffolds. Furthermore, decomposition of the polymer particles during thermal debindering results in the formation of an additional network of interconnecting micropores in the stabilizing structures. It is possible to adjust the porosity easily and quickly in a range of 1.2–140 μm with a relatively low organic fraction. The structures thus prepared showed no cytotoxicity nor negative effects on the biocompatibility. Full article
(This article belongs to the Special Issue Recent Advances of Bone Bioengineering)
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