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Bioengineering
Special Issues
Cartilage and Bone Tissue Engineering for Craniofacial Reconstruction
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Cartilage and Bone Tissue Engineering for Craniofacial Reconstruction

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 1695

Special Issue Editors

Prof. Dr. Deborah Watson

E-Mail Website
Guest Editor
Department of Otolaryngology-Head & Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
Interests: rhinoplasty; nasal reconstruction; human septal cartilage; cartilage tissue engineering
Prof. Dr. Robert L. Sah

E-Mail Website
Guest Editor
Gene Lay-Shu Chien Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
Interests: cartilage; skeletal growth; osteoarthritis; tissue engineering; biomechanics; mechanobiology

Special Issue Information

Dear Colleagues,

The progress made in bone and cartilage tissue engineering over the last two decades has the potential to address some of the reconstructive challenges within the craniofacial and maxillofacial areas. The current barriers to conventional surgical reconstruction in these areas relate to inadequate autologous tissue supply, donor site morbidity, and extrusion or immune rejection with allogenic or alloplastic implant options. Tissue engineering of autologous tissue can bypass these limitations and theoretically offer grafts in shapes and sizes required for the reconstructive goals. In addition, new technologies in bioprinting can advance the fabrication of new tissue. This Special Issue on “Cartilage and Bone Tissue Engineering for Craniofacial Reconstruction” summarizes current methodologies, highlights recent advances, and presents innovative adjunctive technologies that are likely to impact this field. The articles for this Special Issue will encompass tissue engineering for nasal and ear cartilage reconstruction, bone tissue engineering for craniofacial and maxillofacial areas, and temporomandibular joint regeneration. Experts renowned in the field of tissue engineering are invited to provide their perspective in this Special Issue through submissions focusing on primary work performed in their laboratories or a review of current practices.

Prof. Dr. Deborah Watson
Prof. Dr. Robert L. Sah
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • craniofacial
  • cartilage tissue engineering
  • bone tissue engineering
  • tissue culture
  • cartilage scaffolds
  • tissue regeneration

Published Papers (1 paper)

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Research

16 pages, 3453 KiB  
Article
Alginate Conjugation Increases Toughness in Auricular Chondrocyte Seeded Collagen Hydrogels
by Leigh Slyker and Lawrence J. Bonassar
Bioengineering 2023, 10(9), 1037; https://doi.org/10.3390/bioengineering10091037 - 04 Sep 2023
Viewed by 1322
Abstract
Current auricular cartilage replacements for pediatric microtia fail to address the need for long-term integration and neocartilage formation. While collagen hydrogels have been successful in fostering neocartilage formation, the toughness and extensibility of these materials do not match that of native tissue. This [...] Read more.
Current auricular cartilage replacements for pediatric microtia fail to address the need for long-term integration and neocartilage formation. While collagen hydrogels have been successful in fostering neocartilage formation, the toughness and extensibility of these materials do not match that of native tissue. This study used the N-terminal functionalization of collagen with alginate oligomers to improve toughness and extensibility through metal–ion complexation. Alginate conjugation was confirmed via FTIR spectroscopy. The retention of native collagen fibrillar structure, thermal gelation, and helical conformation in functionalized gels was confirmed via scanning electron microscopy, oscillatory shear rheology, and circular dichroism spectroscopy, respectively. Alginate–calcium complexation enabled a more than two-fold increase in modulus and work density in functionalized collagen with the addition of 50 mM CaCl2, whereas unmodified collagen decreased in both modulus and work density with increasing calcium concentration. Additionally, the extensibility of alginate-functionalized collagen was increased at 25 and 50 mM CaCl2. Following 2-week culture with auricular chondrocytes, alginate-functionalization had no effect on the cytocompatibility of collagen gels, with no effects on cell density, and increased glycosaminoglycan deposition. Custom MATLAB video analysis was then used to quantify fracture toughness, which was more than 5-fold higher following culture in functionalized collagen and almost three-fold higher in unmodified collagen. Full article
(This article belongs to the Special Issue Cartilage and Bone Tissue Engineering for Craniofacial Reconstruction)
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