Protein Therapy for Cardiovascular Disease Treatment

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 82

Special Issue Editors

E-Mail Website
Guest Editor
Department of Surgery, University of Virginia, Charlottesville, VA 22903, USA
Interests: regenerative medicine; cardiovascular diseases; aging; cancer biology; diabetes

E-Mail Website
Guest Editor
Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA 22903, USA
Interests: muscle physiology; ion channels; protein therapeutics; regenerative medicine

Special Issue Information

Dear Colleagues,

Myocardial infarction (MI) occurs due to the blockage of coronary arteries, leading to ischemia of the myocardium and inflammatory cell death. The dead cardiac tissue is replaced by fibrous scar tissue, causing a decline in myocardial contractile strength and impacting the functional capacity of the heart. While treatments such as stent placement, vascular bypass, and transplantation are beneficial, they have limitations. There is an urgent need to develop novel protein therapeutics to control inflammation and to improve the regenerative capacity of the heart in the setting of acute MI and chronic heart failure.

New approaches involving biologics, cell-based, or a combination of biologics and cell therapies are emerging as potential means for cardiovascular diseases. The development of an effective delivery system is crucial to ensure that therapeutic proteins reach the target tissues in the body. The exploration of various methods, including injections, implants, and other advanced drug and cell delivery technologies, is essential for this purpose.

Prof. Dr. Jianjie Ma
Dr. Ki Ho Park
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • myocardial infarction
  • heart failure
  • vein graft
  • intimal hyperplasia
  • aneurysm
  • stem cells
  • nanoparticle
  • transplantation
  • MyoAAV
  • tissue repair
  • inflammation

Published Papers

This special issue is now open for submission.
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