Biological Tissue Regeneration Using Medical Materials

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1177

Special Issue Editors

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Guest Editor
Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan
Interests: grafting & therapeutic materials; tissue regeneration (skin, nerve, cartilage/bone, blood vessel, dura mater, and tendon); reconstructive surgery

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Guest Editor
Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Interests: ceramics; calcium phosphate materials; scaffold; bone regeneration

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Guest Editor
Clinical division of Plastic and Reconstructive Surgery, Yamagata University Hospital, Yamagata 990-9585, Japan
Interests: wound healing; burn healing; bone reconstruction; scar contracture; plastic and reconstructive surgery; hand surgery

Special Issue Information

Dear Colleagues,

Biological tissue regeneration using medical materials such as collagen, gel, ceramics, polymers, and metals is drawing attention. Medical materials are appropriately designed to be minimally invasive and endogenously non-toxic, and their application is expected to promote tissue regeneration. In vitro evaluation using medical materials is important for tissue regeneration. Furthermore, in vivo evaluation using animal models is essential to ensure the safety of medical materials for living organisms before clinical trials. Such in vivo research on tissue regeneration using medical materials covers a wide range of fields, including skin, bone/cartilage, nerve, fascia/dura mater, etc. The research boundary between medicine and engineering will provide novel useful treatments for various diseases in the future. Original articles on new medical materials, in vivo/in vitro evaluation methods for regenerated tissues, and new knowledge to the advance medical care are welcome for this Special Issue. The specific topics of interest are as follows:

  • In vivo evaluation of the effects of medical materials in animal models and clinical trials, including tissue regeneration (bone, skin, nerve, cartilage, blood vessel, tendon, etc.) and medical materials (ceramics, polymers, metals, collagen, gel, etc.).
  • The interaction of medical materials with cells such as stem cells, fibroblasts, osteoblasts, etc.
  • In vitro evaluation of differentiation and proliferation on the surfaces of medical materials.
  • The functional evaluation of organs and vital tissues organized on/at the surface of medical materials.

Prof. Dr. Osamu Yamamoto
Prof. Dr. Osamu Suzuki
Dr. Norio Fukuda
Guest Editors

Manuscript Submission Information

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  • ceramics
  • polymers
  • metals
  • gel
  • collagen
  • in vivo/in vitro evaluation
  • cells
  • animal model
  • clinical trial
  • biological tissue regeneration

Published Papers (1 paper)

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19 pages, 11990 KiB  
Nerve Regeneration and Gait Function Recovery with Implantation of Glucose/Mannose Conduits Using a Rat Model: Efficacy of Glucose/Mannose as a New Neurological Guidance Material
by Osamu Yamamoto, Risa Saito, Yuta Ohseki and Asami Hoshino
Bioengineering 2024, 11(2), 157; - 4 Feb 2024
Viewed by 917
Therapy with clinical nerve guidance conduits often causes functional incompleteness in patients. With the aim of better therapeutic efficacy, nerve regeneration and gait function were investigated in this study using a novel nerve guidance conduit consisting of glucose/mannose. The glucose/mannose nerve guidance conduits [...] Read more.
Therapy with clinical nerve guidance conduits often causes functional incompleteness in patients. With the aim of better therapeutic efficacy, nerve regeneration and gait function were investigated in this study using a novel nerve guidance conduit consisting of glucose/mannose. The glucose/mannose nerve guidance conduits were prepared by filling the conduits with the glucose/mannose aqueous solutions for different kinematic viscosity, which were applied to sciatic nerve defects (6 mm gap) in a rat model. The nerve regeneration effect and the gait function recovery with the fabricated nerve guidance conduits were examined. From the results of the XRD measurement, the glucose/mannose conduits were identified as crystal structures of cellulose type II. Young’s modulus and the maximum tensile strength of the crystalline glucose/mannose conduits demonstrated good strength and softness for the human nerve. Above 4 weeks postoperative, macroscopic observation revealed that the nerve was regenerated in the defective area. In various staining results of the nerve tissue removed at 4 weeks postoperative, myelinated nerves contributing to gait function could not be observed in the proximal and distal sites to the central nerve. At 8–12 weeks postoperative, myelinated nerves were found at the proximal and distal sites in hematoxylin/eosin staining. Glia cells were confirmed by phosphotungstic acid–hematoxylin staining. Continuous nerve fibers were observed clearly in the sections of the regenerated nerves towards the longitudinal direction at 12 weeks postoperative. The angle between the metatarsophalangeal joint and the ground plane was approximately 93° in intact rats. At 4 weeks postoperative, walking was not possible, but at 8 weeks postoperative, the rats were able to walk, with an angle of 53°. At 12 weeks postoperative, the angle increased further, reaching 65°, confirming that the rats were able to walk more quickly than at 8 weeks postoperative. These results demonstrated that gait function in rats treated with glucose/mannose nerve guidance conduits was rapidly recovered after 8 weeks postoperative. The glucose/mannose nerve guidance conduit could be applied as a new promising candidate material for peripheral nerve regeneration. Full article
(This article belongs to the Special Issue Biological Tissue Regeneration Using Medical Materials)
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