Mechanobiology and Cell Mechanics in Biology and Diseases

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1440

Special Issue Editors

Department of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong, China
Interests: mechanobiology; mechano-oncology; tumor metastasis; cell mechanics; cancer stem cell
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Guest Editor
Department of Mechanical and Aerospace Engineering, J. Crayton Pruitt Family Department of Biomedical Engineering, UF Health Cancer Center, Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
Interests: biophysics and mechanobiology in cancer development and metastasis, cardiovascular system, and brain; all-optical mechano-electrophysiology; functional imaging in vivo; optogenetics; bio-nanotechnology; genome editing

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Guest Editor
Department of Integrative Medical Biology, University of Umea, 901 87 Umea, Sweden
Interests: regenerative medicine; mechanobiology; cartilage tissue engineering; stem cells; osteoarthritis

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Guest Editor
Department of Biomedical, Chemical & Materials Engineering, San José State University, San José, CA 95192, USA
Interests: vascular mechanobiology; hemostasis and thrombosis; platelets

Special Issue Information

Dear Colleagues,

Mechanobiology is an emerging cross-disciplinary area, which analyses the understanding of how mechanical forces influence the functions and structures of biological systems at molecular, cellular, tissue, and body levels. In recent years, there has been a rapid accumulation of evidence surrounding the development of innovative strategies against diseases by targeting mechanical factors and the significance of mechanical signals and cell mechanics in various physiologic and pathologic processes.

This Special Issue on “Mechanobiology and cell mechanics in biology and diseases” focuses on the developments in both fundamental research and engineering methodologies that advance the field of mechanobiology in original research articles and comprehensive reviews. This Special Issue will include, among others, the following topics of interest:

  1. Mechanical characterization of molecules, cells, and tissues in diseases;
  2. Mechanical and biophysical regulation of physiologic and pathologic processes;
  3. Mechanosensing and mechanotransduction at molecular-to-tissue scales;
  4. Multiscale theoretical modeling for the causal understanding of mechanical forces in biology;
  5. Innovative clinical therapeutic strategies by targeting mechanical cues and mechanotransduction;
  6. Advanced engineering tools for measuring/applying mechanical forces in biological systems;

Dr. Youhua Tan
Dr. Tang Xin
Prof. Dr. Mikko J. Lammi
Dr. Anand Ramasubramanian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanobiology
  • mechanotransduction
  • cell mechanics
  • biophysics
  • mechanomedicine
  • mechanical forces
  • mechanotargeting
  • mechano-therapeutics

Published Papers (1 paper)

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Review

23 pages, 1871 KiB  
Review
Natural Killer Cell Mechanosensing in Solid Tumors
by Suzanne Lightsey and Blanka Sharma
Bioengineering 2024, 11(4), 328; https://doi.org/10.3390/bioengineering11040328 - 28 Mar 2024
Viewed by 736
Abstract
Natural killer (NK) cells, which are an exciting alternative cell source for cancer immunotherapies, must sense and respond to their physical environment to traffic to and eliminate cancer cells. Herein, we review the mechanisms by which NK cells receive mechanical signals and explore [...] Read more.
Natural killer (NK) cells, which are an exciting alternative cell source for cancer immunotherapies, must sense and respond to their physical environment to traffic to and eliminate cancer cells. Herein, we review the mechanisms by which NK cells receive mechanical signals and explore recent key findings regarding the impact of the physical characteristics of solid tumors on NK cell functions. Data suggest that different mechanical stresses present in solid tumors facilitate NK cell functions, especially infiltration and degranulation. Moreover, we review recent engineering advances that can be used to systemically study the role of mechanical forces on NK cell activity. Understanding the mechanisms by which NK cells interpret their environment presents potential targets to enhance NK cell immunotherapies for the treatment of solid tumors. Full article
(This article belongs to the Special Issue Mechanobiology and Cell Mechanics in Biology and Diseases)
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