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Bioengineering
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Bioengineering Techniques in Human Microbial Infection: Immune Response and Clinical...
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Bioengineering Techniques in Human Microbial Infection: Immune Response and Clinical Challenges

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biochemical Engineering".

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 6036

Special Issue Editor

Dr. Kandasamy Saravanakumar

E-Mail Website
Guest Editor
Department of Bio Health Convergence, Kangwon National University, Chuncheon 200-701, Republic of Korea
Interests: microbial biotechnology; fungal biology; natural products; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bacterial and fungal infections are highly challenging to treat and showing resistance to most of the existing antimicrobial drugs. The recent increase in multidrug-resistant bacterial infections, and the emergence of deadly fungal infections, place patients, especially post-COVID-19 recovery and among immunocompromised patients, at high risk of organ damage with a higher percentage of fatality. This Special Issue will cover a broad range of combinatorial therapeutic approaches which comprise antibacterial and antifungal responses through the action of natural compounds, peptides, drugs, alternative antifungal compounds, metal/metal oxide nanoparticles, and polymeric nanomaterials. We welcome high-quality reviews and original research articles that address the present scenario of antibacterial and antifungal therapy against pharmaceutically important, multidrug-resistant pathogenic microorganisms.

Dr. Kandasamy Saravanakumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal activity
  • antibacterial activity
  • mechanism of action
  • antimicrobial nanoconjugates
  • synthesis of antifungal and antibacterial compounds
  • drug delivery
  • antifungal metabolites
  • antimicrobial peptides
  • candida
  • yeast
  • aspergillus

Published Papers (2 papers)

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Research

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13 pages, 2497 KiB  
Article
Chain-Engineering-Based De Novo Drug Design against MPXVgp169 Virulent Protein of Monkeypox Virus: A Molecular Modification Approach
by Muhammad Naveed, Muhammad Aqib Shabbir, Noor-ul Ain, Khushbakht Javed, Sarmad Mahmood, Tariq Aziz, Ayaz Ali Khan, Ghulam Nabi, Muhammad Shahzad, Mousa Essa Alharbi, Metab Alharbi and Abdulrahman Alshammari
Bioengineering 2023, 10(1), 11; https://doi.org/10.3390/bioengineering10010011 - 21 Dec 2022
Cited by 14 | Viewed by 1991
Abstract
The unexpected appearance of the monkeypox virus and the extensive geographic dispersal of cases have prompted researchers to concentrate on potential therapeutic approaches. In addition to its vaccine build techniques, there should be some multiple integrated antiviral active compounds because of the MPV [...] Read more.
The unexpected appearance of the monkeypox virus and the extensive geographic dispersal of cases have prompted researchers to concentrate on potential therapeutic approaches. In addition to its vaccine build techniques, there should be some multiple integrated antiviral active compounds because of the MPV (monkeypox virus) outbreak in 2022. This study offers a computational engineering-based de novo drug discovery mediated by random antiviral active compounds that were screened against the virulent protein MPXVgp169, as one of the key players directing the pathogenesis of the virus. The screening of these candidates was supported by the use of 72 antiviral active compounds. The top candidate with the lowest binding affinity was selected for the engineering of chains or atoms. Literature assisted to identify toxic chains or atoms that were impeding the stability and effectiveness of antiviral compounds to modify them for enhanced efficacy. With a binding affinity of −9.4 Kcal/mol after chain, the lipophilicity of 0.41, the water solubility of 2.51 as soluble, and synthetic accessibility of 6.6, chain-engineered dolutegravir was one of the best active compounds, as proved by the computational engineering analysis. This study will revolutionize the era of drug engineering as a potential therapeutic strategy for monkeypox infection. Full article
(This article belongs to the Special Issue Bioengineering Techniques in Human Microbial Infection: Immune Response and Clinical Challenges)
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Review

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17 pages, 2543 KiB  
Review
Current and Perspective Sensing Methods for Monkeypox Virus
by Ijaz Gul, Changyue Liu, Xi Yuan, Zhicheng Du, Shiyao Zhai, Zhengyang Lei, Qun Chen, Muhammad Akmal Raheem, Qian He, Qiuyue Hu, Chufan Xiao, Zhang Haihui, Runming Wang, Sanyang Han, Ke Du, Dongmei Yu, Can Yang Zhang and Peiwu Qin
Bioengineering 2022, 9(10), 571; https://doi.org/10.3390/bioengineering9100571 - 18 Oct 2022
Cited by 31 | Viewed by 3513
Abstract
The outbreak of the monkeypox virus (MPXV) in non-endemic countries is an emerging global health threat and may have an economic impact if proactive actions are not taken. As shown by the COVID-19 pandemic, rapid, accurate, and cost-effective virus detection techniques play a [...] Read more.
The outbreak of the monkeypox virus (MPXV) in non-endemic countries is an emerging global health threat and may have an economic impact if proactive actions are not taken. As shown by the COVID-19 pandemic, rapid, accurate, and cost-effective virus detection techniques play a pivotal role in disease diagnosis and control. Considering the sudden multicountry MPXV outbreak, a critical evaluation of the MPXV detection approaches would be a timely addition to the endeavors in progress for MPXV control and prevention. Herein, we evaluate the current MPXV detection methods, discuss their pros and cons, and provide recommended solutions to the problems. We review the traditional and emerging nucleic acid detection approaches, immunodiagnostics, whole-particle detection, and imaging-based MPXV detection techniques. The insights provided in this article will help researchers to develop novel techniques for the diagnosis of MPXV. Full article
(This article belongs to the Special Issue Bioengineering Techniques in Human Microbial Infection: Immune Response and Clinical Challenges)
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