Recent Advances in Biomaterials for Mechanobiology and Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1690

Special Issue Editor


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Guest Editor
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
Interests: polysaccharides; chitosans; fabrication of innovative hydrogels; hydrogel-to-cell interplay; mechanobiology; regenerative medicine
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Special Issue Information

Dear Colleagues,

There is growing evidence that the mechanical properties of bioinspired materials that mimic natural extracellular matrices are robust controllers of cell-fate decisions. The recapitulation of mechanical properties such as stress relaxation, overall stiffness and, more recently, the extent of the linear stress–strain region is indeed an attractive topic. Huge efforts are currently being made to assemble 2D and 3D biomaterials to study cell response, which could have implications for areas such as mechanobiology and, more broadly, tissue engineering. The search for innovative polymers, right down to their assembly, is being assiduously pursued in order to gain fundamental knowledge in this field.

The aim of this Special Issue is to bring together researchers working on the development of biomaterials and related applications in mechanobiology and tissue engineering. A range of topics of great interest are welcome, including, but not limited to, chemical modifications of polymers to modulate the resulting material mechanics, stimuli-responsive biomaterials, the interplay of biomaterials and cells in both 2D and 3D environments, recent developments in smart polymers and biomaterials related to mechanobiology and tissue engineering, to name a few.

Dr. Pasquale Sacco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials development
  • biomaterials-to-cell interplay
  • mechanical properties
  • mechanobiology
  • tissue engineering

Published Papers (1 paper)

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Research

12 pages, 2974 KiB  
Article
Tunable Double-Network GelMA/Alginate Hydrogels for Platelet Lysate-Derived Protein Delivery
by Andrea Marfoglia, Fahd Tibourtine, Ludovic Pilloux and Sophie Cazalbou
Bioengineering 2023, 10(9), 1044; https://doi.org/10.3390/bioengineering10091044 - 5 Sep 2023
Cited by 2 | Viewed by 1283
Abstract
Hydrogels (gels) are attractive tools for tissue engineering and regenerative medicine due to their potential for drug delivery and ECM-like composition. In this study, we use rheology to characterize GelMA/alginate gels loaded with human platelet lysate (PL). We then characterize these gels from [...] Read more.
Hydrogels (gels) are attractive tools for tissue engineering and regenerative medicine due to their potential for drug delivery and ECM-like composition. In this study, we use rheology to characterize GelMA/alginate gels loaded with human platelet lysate (PL). We then characterize these gels from a physicochemical perspective and evaluate their ability to transport PL proteins, their pore size, and their rate of degradation. Finally, their biocompatibility is evaluated. We describe how alginate changes the mechanical behavior of the gels from elastic to viscoelastic after ionic (calcium-mediated) crosslinking. In addition, we report the release of ~90% of PL proteins from the gels and relate it to the degradation profile of the gels. Finally, we evaluated the biocompatibility of the gels. Thus, the developed gels represent attractive substrates for both cell studies and as bioactive materials. Full article
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