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Bioengineering
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Feature Papers in Biofabrication and Biomanufacturing
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Feature Papers in Biofabrication and Biomanufacturing

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biofabrication and Biomanufacturing".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 6838

Special Issue Editor

Dr. Mahmoud Amouzadeh Tabrizi

E-Mail Website
Guest Editor
Electronic Technology Department, Universidad Carlos III de Madrid, 28911 Leganés, Spain
Interests: biosensors; electrochemistry; point of care devices; nanomaterials; surface modification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the high impact of bio-fabrication and biomanufacturing technology in our life, in this Special Issue, we are planning to collect high-quality research articles, short communications, and review articles in this field. Nowadays, thanks to advances in biofabrication and biomanufacturing, several artificial biodevices have been fabricated. These artificial biodevices help us detect the biomolecules at a trace level, measure the tension force between the cells, release the controllable drugs, decompose the biomolecules, etc. In the progress of fabrication and biomanufacturing, the nano/micro materials play key roles via increasing the sensitivity of the biosensing devices, increasing the surface coverage of the biomolecules, decreasing the size of the device, and decreasing the cost. Hence, in this section, we will collect novel research works that use nano/micro materials for biofabrication and biomanufacturing. Topics include, but are not limited to, the following: nanobiosensor, nanoswimmers, microchip, biomicro-electromechanical systems, 3D bioprinting of tissues, bioimaging, and decomposition of biomolecues. We look forward to receiving your manuscript.

Dr. Mahmoud Amouzadeh Tabrizi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial bioreceptors
  • antibody
  • microneedle
  • biosensor
  • electrochemical decomposition

Published Papers (4 papers)

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Research

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20 pages, 8863 KiB  
Article
Long-Term Culture Performance of a Polyelectrolyte Complex Microcapsule Platform for Hyaline Cartilage Repair
by Ehinor P. Arhebamen, Maria T. Teodoro, Amelia B. Blonka and Howard W. T. Matthew
Bioengineering 2023, 10(4), 467; https://doi.org/10.3390/bioengineering10040467 - 12 Apr 2023
Viewed by 1364
Abstract
Articular cartilage (AC) tissue repair and regeneration remains an ongoing challenge. One component of the challenge is the limited ability to scale an engineered cartilage graft to clinically relevant sizes while maintaining uniform properties. In this paper, we report on the evaluation of [...] Read more.
Articular cartilage (AC) tissue repair and regeneration remains an ongoing challenge. One component of the challenge is the limited ability to scale an engineered cartilage graft to clinically relevant sizes while maintaining uniform properties. In this paper, we report on the evaluation of our polyelectrolyte complex microcapsule (PECM) platform technology as a technique for generating cartilage-like spherical modules. Bone marrow-derived mesenchymal stem cells (bMSCs) or primary articular chondrocytes were encapsulated within PECMs composed of methacrylated hyaluronan, collagen I, and chitosan. The formation of cartilage-like tissue in the PECMs over a 90-day culture was characterized. The results showed that chondrocytes exhibited superior growth and matrix deposition compared to either chondrogenically-induced bMSCs or a mixed PECM culture containing both chondrocytes and bMSCs. The chondrocyte-generated matrix filled the PECM and produced substantial increases in capsule compressive strength. The PECM system thus appears to support intracapsular cartilage tissue formation and the capsule approach promotes efficient culture and handling of these micro tissues. Since previous studies have proven the feasibility of fusing such capsules into large tissue constructs, the results suggest that encapsulating primary chondrocytes in PECM modules may be a viable route toward achieving a functional articular cartilage graft. Full article
(This article belongs to the Special Issue Feature Papers in Biofabrication and Biomanufacturing)
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Review

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20 pages, 2329 KiB  
Review
Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges
by Abdullah Jabri, Jibran Khan, Bader Taftafa, Mohamed Alsharif, Abdulaziz Mhannayeh, Raja Chinnappan, Alaa Alzhrani, Shadab Kazmi, Mohammad Shabab Mir, Aljohara Waleed Alsaud, Ahmed Yaqinuddin, Abdullah M. Assiri, Khaled AlKattan, Yogesh K. Vashist, Dieter C. Broering and Tanveer Ahmad Mir
Bioengineering 2024, 11(4), 346; https://doi.org/10.3390/bioengineering11040346 - 01 Apr 2024
Viewed by 601
Abstract
Hepatic cancer is widely regarded as the leading cause of cancer-related mortality worldwide. Despite recent advances in treatment options, the prognosis of liver cancer remains poor. Therefore, there is an urgent need to develop more representative in vitro models of liver cancer for [...] Read more.
Hepatic cancer is widely regarded as the leading cause of cancer-related mortality worldwide. Despite recent advances in treatment options, the prognosis of liver cancer remains poor. Therefore, there is an urgent need to develop more representative in vitro models of liver cancer for pathophysiology and drug screening studies. Fortunately, an exciting new development for generating liver models in recent years has been the advent of organoid technology. Organoid models hold huge potential as an in vitro research tool because they can recapitulate the spatial architecture of primary liver cancers and maintain the molecular and functional variations of the native tissue counterparts during long-term culture in vitro. This review provides a comprehensive overview and discussion of the establishment and application of liver organoid models in vitro. Bioengineering strategies used to construct organoid models are also discussed. In addition, the clinical potential and other relevant applications of liver organoid models in different functional states are explored. In the end, this review discusses current limitations and future prospects to encourage further development. Full article
(This article belongs to the Special Issue Feature Papers in Biofabrication and Biomanufacturing)
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0 pages, 3816 KiB  
Review
Whole Liver Derived Acellular Extracellular Matrix for Bioengineering of Liver Constructs: An Updated Review
by Tanveer Ahmed Mir, Alaa Alzhrani, Makoto Nakamura, Shintaroh Iwanaga, Shadil Ibrahim Wani, Abdullah Altuhami, Shadab Kazmi, Kenichi Arai, Talal Shamma, Dalia A. Obeid, Abdullah M. Assiri and Dieter C. Broering
Bioengineering 2023, 10(10), 1126; https://doi.org/10.3390/bioengineering10101126 - 25 Sep 2023
Cited by 1 | Viewed by 1364
Abstract
Biomaterial templates play a critical role in establishing and bioinstructing three-dimensional cellular growth, proliferation and spatial morphogenetic processes that culminate in the development of physiologically relevant in vitro liver models. Various natural and synthetic polymeric biomaterials are currently available to construct biomimetic cell [...] Read more.
Biomaterial templates play a critical role in establishing and bioinstructing three-dimensional cellular growth, proliferation and spatial morphogenetic processes that culminate in the development of physiologically relevant in vitro liver models. Various natural and synthetic polymeric biomaterials are currently available to construct biomimetic cell culture environments to investigate hepatic cell–matrix interactions, drug response assessment, toxicity, and disease mechanisms. One specific class of natural biomaterials consists of the decellularized liver extracellular matrix (dECM) derived from xenogeneic or allogeneic sources, which is rich in bioconstituents essential for the ultrastructural stability, function, repair, and regeneration of tissues/organs. Considering the significance of the key design blueprints of organ-specific acellular substrates for physiologically active graft reconstruction, herein we showcased the latest updates in the field of liver decellularization–recellularization technologies. Overall, this review highlights the potential of acellular matrix as a promising biomaterial in light of recent advances in the preparation of liver-specific whole organ scaffolds. The review concludes with a discussion of the challenges and future prospects of liver-specific decellularized materials in the direction of translational research. Full article
(This article belongs to the Special Issue Feature Papers in Biofabrication and Biomanufacturing)
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29 pages, 3035 KiB  
Review
Additive Manufacturing Using Agriculturally Derived Biowastes: A Systematic Literature Review
by Al Mazedur Rahman, Taieba Tuba Rahman, Zhijian Pei, Chukwuzubelu Okenwa Ufodike, Jaesung Lee and Alaa Elwany
Bioengineering 2023, 10(7), 845; https://doi.org/10.3390/bioengineering10070845 - 17 Jul 2023
Cited by 6 | Viewed by 2949
Abstract
Agriculturally derived biowastes can be transformed into a diverse range of materials, including powders, fibers, and filaments, which can be used in additive manufacturing methods. This review study reports a study that analyzes the existing literature on the development of novel materials from [...] Read more.
Agriculturally derived biowastes can be transformed into a diverse range of materials, including powders, fibers, and filaments, which can be used in additive manufacturing methods. This review study reports a study that analyzes the existing literature on the development of novel materials from agriculturally derived biowastes for additive manufacturing methods. A review was conducted of 57 selected publications since 2016 covering various agriculturally derived biowastes, different additive manufacturing methods, and potential large-scale applications of additive manufacturing using these materials. Wood, fish, and algal cultivation wastes were also included in the broader category of agriculturally derived biowastes. Further research and development are required to optimize the use of agriculturally derived biowastes for additive manufacturing, particularly with regard to material innovation, improving print quality and mechanical properties, as well as exploring large-scale industrial applications. Full article
(This article belongs to the Special Issue Feature Papers in Biofabrication and Biomanufacturing)
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