Modern Insight into Tissue Regeneration and Cell Therapy in Medical Research: Updates and Directions

Dear Colleagues,

Over the last few decades, great strides have been made in our comprehension of the potential of targeted cell-based and tissue engineering strategies. Aesthetic and reconstructive applications have led the way due to constant challenges resulting from injury, loss of circulatory capacity, degenerative paths, and repair, which put high demand on optimal approaches to structural and regenerative needs. In particular, autologous and allogenic cell-based therapies for skin and cartilage affections have been clinically implemented at large scales in the 20th century, while current interests notably revolve around hematologic or oncology-related therapeutic indications. The industrialization of cell source procurement and processing has had a pivotal impact in health care for nearly one hundred years, with the necessity of potent and stable cell sources for vaccine development, drug discovery, and testing assays and more recently for patient-targeted cell therapies for disease treatments. Cellular-based therapies provide alternative means to classical medications and can easily be implemented in parallel and provide important surgically assisted measures for the repair and regeneration of tissues. Topics of interest for this Special Issue include, but are not limited to, the following:

• Advances in tissue engineering technologies;
• Cartilage repair and wound healing;
• Tissue reconstruction;
• Cell-based surgical enhancement;
• Cell banking;
• Biomaterials and scaffold developments;
• Growth, remodeling, and repair in biological tissues;
• In vivo assessment of tissue repair;
• Molecular and cellular biomechanics;

Dr. Lee Ann Laurent-Applegate
Dr. Philippe Abdel-Sayed
Guest Editors

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• cellular therapy
• regenerative medicine
• tissue repair
• wound healing
• biomaterials
• oxidative stress