Ultra-Short Pulse Laser Sources for Bone Tissue Ablation

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 387

Special Issue Editors

ALPhANOV Centre Technologique Optique et Lasers, Talence, France
Interests: femtosecond laser; laser processing development; biomedical applications
Mechanical and Biomedical Engineering, University of Texas at Austin, Austin, TX, USA
Interests: femtosecond laser surgery; nonlinear microscopy; biomedical engineering; high-throughput microfluidics with applications to nerve regeneration and degeneration; stem cells; RNA-sequencing

Special Issue Information

Dear Colleagues,

Laser technology is nowadays the technique of choice for a wide range of biomedical applications thanks to its ability to guarantee an unmatched ablation precision and to work with a contactless approach. In this context, the clinical exploitation of ultra-short-pulse lasers (UPS) still remains limited to a few applications in specific fields, such as ophthalmology and dermatology, mainly because of the low productivity regimes that are associated with these types of laser sources. However, recent advancements in photonics technology, such as the possibility to deliver USPs at a high average power and to transport them through optical fibres, have opened up the way to new possible application fields, for instance in osteotomy and urology. The treatment of bone tissue by USP laser sources relies on the unique properties of such laser sources to avoid thermal damage to the surrounding tissue and therefore improve its overall recovery time. Following the take-up of this technology, important steps forward could be foreseen in several clinical applications, such as bone scaffolding and replacement, micro-surgeries, or specific craniotomy techniques.

 The topics of interest of this Special Issue include, but are not limited to:

  • In vivo and ex vivo fundamental studies on USP laser–bone tissue interaction;
  • Living cells’ interaction with USP-treated bone tissue (bioprinting processes);
  • Real-time characterisation of bone tissue properties during USP ablation;
  • Process development for high-throughput ablation of bone tissue;
  • Clinical and pre-clinical evaluation of USP laser-based applications in osteotomy procedures;
  • Device integration and process control for clinical exploitation of USP laser technology in osteotomy procedures.

Dr. Laura Gemini
Prof. Dr. Adela Ben-Yakar
Guest Editors

Manuscript Submission Information

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Keywords

  • ultra-short-pulse lasers
  • femtosecond lasers
  • picosecond lasers
  • bone tissue
  • osteotomy

Published Papers (1 paper)

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Research

15 pages, 5675 KiB  
Article
Real-Time Monitoring of Thermal Phenomena during Femtosecond Ablation of Bone Tissue for Process Control
by Samy Al-Bourgol, Guillaume Machinet, Aboubakr Bakkali, Marc Faucon and Laura Gemini
Bioengineering 2024, 11(4), 309; https://doi.org/10.3390/bioengineering11040309 - 26 Mar 2024
Viewed by 173
Abstract
Femtosecond (fs) laser technology is currently being considered in innovative fields such as osteotomy and treatment of hard tissue thanks to the achievable high resolution and ability to prevent tissue damage. In a previous study, suitable process parameters were obtained to achieve competitive [...] Read more.
Femtosecond (fs) laser technology is currently being considered in innovative fields such as osteotomy and treatment of hard tissue thanks to the achievable high resolution and ability to prevent tissue damage. In a previous study, suitable process parameters were obtained to achieve competitive ablation rates on pork femur processing. Nevertheless, a better control of thermal accumulation in the tissue during laser ablation could further improve the postoperative regeneration of the treated bone compared with conventional procedures and push forward the exploitation of such technology. This study presents methods for real time analyses of bone tissue temperature and composition during fs laser ablation and highlights the importance of implementing an efficient cooling method of bone tissue in order to achieve optimized results. Results show that it is possible to achieve a larger process window for bone tissue ablation where bone tissue temperature remains within the protein denaturation temperature in water-based processing environment. This is a key outcome towards a clinical exploitation of the presented technology, where higher process throughputs are necessary. The effects of process parameters and environments on bone tissue were confirmed by LIBS technique, which proved to be an efficient method by which to record real-time variation of bone tissue composition during laser irradiation. Full article
(This article belongs to the Special Issue Ultra-Short Pulse Laser Sources for Bone Tissue Ablation)
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