Biomechanics Analysis in Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 3285

Special Issue Editors

CDRsp and School of Technology and Management, Polytechnic of Leiria, Leiria, Portugal
Interests: biomechanics; finite element method; optimization; mesh generation; isogeometric analysis; image segmentation; isogeometric analysis
1. UNIDEMI, Department of Mechanical and Industrial Engineering, NOVA School of Science and Technology, 2829-516 Caparica, Portugal
2. Laboratório Associado de Sistemas Inteligentes, LASI, 4800-058 Guimarães, Portugal
Interests: biomechanics; finite element method; multibody systems dynamics; optimization; machine learning
BioMécanique et BioIngénierie (BMBI), Université de Technologie de Compiègne: Compiegne, Île-de-France, France
Interests: mechanical properties; numerical modeling engineering; finite element analysis

Special Issue Information

Dear Colleagues,

Tissue engineering is a multidisciplinary field and essential in the treatment of various pathologies, from the musculoskeletal system to the respiratory system.

Tissue engineering is a type of multiscale engineering, from cell analysis behavior to full tissue adaptation to different biologic and mechanical stimuli. For instance, biological responses to stent’s implantation is a dynamic process, and is related to external tissue stimuli.

This Special Issue on “Biomechanics Analysis in Tissue Engineering” will therefore focus on original research papers, dealing with experimental and computational tissue engineering methodologies. Topics of interest for this Special Issue include, but are not limited to, the following:

  • Tissue engineering scaffold design;
  • Multidisciplinary optimization methods;
  • Modelling scaffold material behavior;
  • Modelling biological tissue performance;
  • Predictive models for tissue engineering;
  • Multiscale patient specific simulations;
  • Fluid–structure interaction modelling;
  • New computational methods for tissue engineering, including machine learning and other artificial-intelligence-based techniques.

Dr. Rui B. Ruben
Dr. Marta Carvalho
Dr. Olfa Trabelsi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • computational bioengineering
  • computational fluid dynamics
  • experimental tissue engineering

Published Papers (2 papers)

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Research

19 pages, 5288 KiB  
Article
Mechanical Characterization of the Human Abdominal Wall Using Uniaxial Tensile Testing
by Kyleigh Kriener, Raushan Lala, Ryan Anthony Peter Homes, Hayley Finley, Kate Sinclair, Mason Kelley Williams and Mark John Midwinter
Bioengineering 2023, 10(10), 1213; https://doi.org/10.3390/bioengineering10101213 - 17 Oct 2023
Cited by 1 | Viewed by 1689
Abstract
It is generally accepted that the human abdominal wall comprises skin, subcutaneous tissues, muscles and their aponeuroses, and the parietal peritoneum. Understanding these layers and their mechanical properties provides valuable information to those designing procedural skills trainers, supporting surgical procedures (hernia repair), and [...] Read more.
It is generally accepted that the human abdominal wall comprises skin, subcutaneous tissues, muscles and their aponeuroses, and the parietal peritoneum. Understanding these layers and their mechanical properties provides valuable information to those designing procedural skills trainers, supporting surgical procedures (hernia repair), and engineering-based work (in silico simulation). However, there is little literature available on the mechanical properties of the abdominal wall in layers or as a composite in the context of designing a procedural skills trainer. This work characterizes the tensile properties of the human abdominal wall by layer and as a partial composite. Tissues were collected from fresh-never-frozen and fresh-frozen cadavers and tested in uniaxial tension at a rate of 5 mm/min until failure. Stress–strain curves were created for each sample, and the values for elastic moduli, ultimate tensile strength, and strain at failure were obtained. The experimental outcomes from this study demonstrated variations in tensile properties within and between tissues. The data also suggest that the tensile properties of composite abdominal walls are not additive. Ultimately, this body of work contributes to a deeper comprehension of these mechanical properties and will serve to enhance patient care, refine surgical interventions, and assist with more sophisticated engineering solutions. Full article
(This article belongs to the Special Issue Biomechanics Analysis in Tissue Engineering)
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13 pages, 1081 KiB  
Article
Measuring Bone Healing: Parameters and Scores in Comparison
by Nicolas Söhling, Olivia Von Jan, Maren Janko, Christoph Nau, Ulrike Ritz, Ingo Marzi, Dirk Henrich and René D. Verboket
Bioengineering 2023, 10(9), 1011; https://doi.org/10.3390/bioengineering10091011 - 26 Aug 2023
Cited by 1 | Viewed by 1071
Abstract
(1) Background: Bone healing is a complex process that can not be replicated in its entirety in vitro. Research on bone healing still requires the animal model. The critical size femur defect (CSFD) in rats is a well-established model for fractures in humans [...] Read more.
(1) Background: Bone healing is a complex process that can not be replicated in its entirety in vitro. Research on bone healing still requires the animal model. The critical size femur defect (CSFD) in rats is a well-established model for fractures in humans that exceed the self-healing potential. New therapeutic approaches can be tested here in vivo. Histological, biomechanical, and radiological parameters are usually collected and interpreted. However, it is not yet clear to what extent they correlate with each other and how necessary it is to record all parameters. (2) Methods: The basis for this study was data from three animal model studies evaluating bone healing. The µCT and histological (Movat pentachrome, osteocalcin) datasets/images were reevaluated and correlation analyses were then performed. Two image processing procedures were compared in the analysis of the image data. (3) Results: There was a significant correlation between the histologically determined bone fraction (Movat pentachrome staining) and bending stiffness. Bone fraction determined by osteocalcin showed no prognostic value. (4) Conclusions: The evaluation of the image datasets using ImageJ is sufficient and simpler than the combination of both programs. Determination of the bone fraction using Movat pentachrome staining allows conclusions to be drawn about the biomechanics of the bone. A standardized procedure with the ImageJ software is recommended for determining the bone proportion. Full article
(This article belongs to the Special Issue Biomechanics Analysis in Tissue Engineering)
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